{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T22:26:17Z","timestamp":1780611977501,"version":"3.54.1"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:00:00Z","timestamp":1057017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2003,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Chronic\n            <jats:italic>Bartonella quintana<\/jats:italic>\n            bacteremia is known to occur in homeless people exposed to lice. We present here the results of an open randomized trial performed to evaluate the efficacy of doxycycline in combination with gentamicin in the eradication of\n            <jats:italic>B. quintana<\/jats:italic>\n            bacteremia. From 1 January 2001 to 1 April 2002, homeless people with blood cultures positive for\n            <jats:italic>B. quintana<\/jats:italic>\n            were randomized to receive either no treatment (untreated controls) or a combination of gentamicin (3 mg\/kg of body weight\/day intravenously for 14 days) and doxycycline (200 mg\/day orally for 28 days). Patients were evaluated from the results of blood cultures performed between day 28 (the end of treatment) and day 90 postinclusion. Intention-to-treat analysis of 20 included patients showed eradication of bacteremia in 7 out of 9 treated patients versus 2 out of 11 untreated controls (\n            <jats:italic>P<\/jats:italic>\n            = 0.01). In the per-protocol analysis, eradication was obtained for 7 out of 7 treated patients versus 2 out of 9 untreated controls (\n            <jats:italic>P<\/jats:italic>\n            = 0.003). This study demonstrates the efficiency of the combination of doxycycline and gentamicin in eradicating\n            <jats:italic>B. quintana<\/jats:italic>\n            bacteremia.\n          <\/jats:p>","DOI":"10.1128\/aac.47.7.2204-2207.2003","type":"journal-article","created":{"date-parts":[[2003,6,23]],"date-time":"2003-06-23T19:17:06Z","timestamp":1056395826000},"page":"2204-2207","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":39,"title":["Randomized Open Trial of Gentamicin and Doxycycline for Eradication of\n            <i>Bartonella quintana<\/i>\n            from Blood in Patients with Chronic Bacteremia"],"prefix":"10.1128","volume":"47","author":[{"given":"C.","family":"Foucault","sequence":"first","affiliation":[{"name":"Unite\u0301 des Rickettsies, CNRS UMR 6020, IFR48, Faculte\u0301 de Me\u0301decine, Universite\u0301 de la Me\u0301diterrane\u0301e, 13385 Marseille Cedex 05"},{"name":"Service des Maladies Infectieuses et Tropicales, Ho\u0302pital Nord, Chemin des Bourrelys, 13915 Marseille Cedex 20, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Raoult","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Rickettsies, CNRS UMR 6020, IFR48, Faculte\u0301 de Me\u0301decine, Universite\u0301 de la Me\u0301diterrane\u0301e, 13385 Marseille Cedex 05"},{"name":"Service des Maladies Infectieuses et Tropicales, Ho\u0302pital Nord, Chemin des Bourrelys, 13915 Marseille Cedex 20, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Brouqui","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Rickettsies, CNRS UMR 6020, IFR48, Faculte\u0301 de Me\u0301decine, Universite\u0301 de la Me\u0301diterrane\u0301e, 13385 Marseille Cedex 05"},{"name":"Service des Maladies Infectieuses et Tropicales, Ho\u0302pital Nord, Chemin des Bourrelys, 13915 Marseille Cedex 20, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1093\/clinids\/23.4.756","volume":"23","year":"1996","unstructured":"Brouqui, P., P. Houpikian, H. T. Dupont, P. Toubiana, Y. Obadia, V. Lafay, and D. Raoult. 1996. Survey of the seroprevalence of Bartonella quintana in homeless people. Clin. Infect. Dis.23:756-759.","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901213400303"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1001\/archinte.1996.00440200111014","volume":"156","year":"1996","unstructured":"Comer, J. A., C. Flynn, R. L. Regnery, D. Vlahov, and J. E. Childs. 1996. Antibodies to Bartonella species in inner-city intravenous drug users in Baltimore, Md. Arch. Intern. Med.156:2491-2495.","journal-title":"Arch. Intern. Med."},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1093\/fampra\/18.3.272","volume":"18","year":"2001","unstructured":"Crane, M., and A. M. Warnes. 2001. Primary health care services for single homeless people: defects and opportunities. Fam. 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