{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:11:01Z","timestamp":1790759461318,"version":"4.1.0"},"reference-count":22,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:00:00Z","timestamp":1057017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2003,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The activities of carbapenems against\n            <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n            decreased in the presence of siliconized latex urinary catheters (SLUCs). This effect was associated with the loss of OprD. The zinc that eluted from SLUCs is responsible for this phenomenon. We have found that zinc exerts a negative effect on the expression of OprD, the porin responsible for carbapenem entry into\n            <jats:italic>P. aeruginosa<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.47.7.2313-2315.2003","type":"journal-article","created":{"date-parts":[[2003,6,23]],"date-time":"2003-06-23T19:17:06Z","timestamp":1056395826000},"page":"2313-2315","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":65,"title":["Zinc Eluted from Siliconized Latex Urinary Catheters Decreases OprD Expression, Causing Carbapenem Resistance in\n            <i>Pseudomonas aeruginosa<\/i>"],"prefix":"10.1128","volume":"47","author":[{"given":"M. Carmen","family":"Conejo","sequence":"first","affiliation":[{"name":"Department of Microbiology, School of Medicine, University of Seville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Garci\u0301a","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, University of Seville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Marti\u0301nez-Marti\u0301nez","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, University of Seville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro","family":"Picabea","sequence":"additional","affiliation":[{"name":"Forensic Science Institute, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u0301lvaro","family":"Pascual","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, University of Seville"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.31.9.2366-2370.1993"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.4.1027-1029.1997"},{"key":"e_1_3_2_4_2","first-page":"84.","volume":"17","year":"1985","unstructured":"Floyd, M. 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