{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:13:43Z","timestamp":1790388823924,"version":"4.1.0"},"reference-count":48,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2003,8,1]],"date-time":"2003-08-01T00:00:00Z","timestamp":1059696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            A novel membrane-associated protein, MsrR, was identified in\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            which affects resistance to methicillin and teicoplanin, as well as the synthesis of virulence factors. MsrR belongs to the LytR-CpsA-Psr family of cell envelope-related transcriptional attenuators and was shown to be inducible by cell wall-active agents, such as \u03b2-lactams, glycopeptides, and lysostaphin. The expression of\n            <jats:italic>msrR<\/jats:italic>\n            peaked in the early exponential growth phase and decreased sharply thereafter.\n            <jats:italic>msrR<\/jats:italic>\n            mutants showed increased\n            <jats:italic>sarA<\/jats:italic>\n            transcription and an earlier and higher expression of RNAIII, resulting in altered expression of virulence factors such as alpha-toxin and protein A. These observations suggest that MsrR is a new component involved in\n            <jats:italic>sarA<\/jats:italic>\n            attenuation and the regulatory network controlling virulence gene expression in\n            <jats:italic>S. aureus<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.47.8.2558-2564.2003","type":"journal-article","created":{"date-parts":[[2003,7,23]],"date-time":"2003-07-23T19:24:32Z","timestamp":1058988272000},"page":"2558-2564","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":72,"title":["MsrR, a Putative Cell Envelope-Associated Element Involved in\n            <i>Staphylococcus aureus sarA<\/i>\n            Attenuation"],"prefix":"10.1128","volume":"47","author":[{"given":"Jutta","family":"Rossi","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology, University of Zu\u0308rich, CH-8028 Zu\u0308rich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Bischoff","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, University of Zu\u0308rich, CH-8028 Zu\u0308rich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihito","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Microbiology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, 162-8640 Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Berger-Ba\u0308chi","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, University of Zu\u0308rich, CH-8028 Zu\u0308rich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80360-2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1078\/1438-4221-00112"},{"key":"e_1_3_2_4_2","unstructured":"Ausubel F. 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