{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T08:54:19Z","timestamp":1760345659295},"reference-count":37,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2003,8,1]],"date-time":"2003-08-01T00:00:00Z","timestamp":1059696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Organisms producing extended-spectrum \u03b2-lactamases (ESBLs) have been reported in many countries, but there is no information on the prevalence of ESBL-producing members of the family\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            in Ireland. A total of 925 isolates of ampicillin-resistant members of the\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            were received from six hospitals in Ireland over a 3-year period from September 1996 to September 1999. Isolates were screened for ESBL production by the double-disk diffusion (DDD) method. DDD-positive isolates that were (i) confirmed as ESBL producers by National Committee for Clinical Laboratory Standards (NCCLS) confirmatory testing and (ii) susceptible to cefoxitin by disk diffusion were considered ESBL producers. By these criteria, 27 (3%) of the ampicillin-resistant members of the\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            studied were categorized as ESBL producers. Molecular typing suggested that some intra- and interhospital spread of ESBL-producing isolates had occurred. DNA sequencing of amplified\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>TEM<\/jats:sub>\n            and\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>SHV<\/jats:sub>\n            genes resulted in the detection of a novel\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>TEM<\/jats:sub>\n            ESBL gene,\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>TEM-102<\/jats:sub>\n            in two isolates (\n            <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n            and\n            <jats:italic>Enterobacter cloacae<\/jats:italic>\n            ) received from the same hospital but isolated from different patients. The study suggests dissemination of ESBL-producing bacteria within the health care system in Ireland and emphasizes the need for measures to control such spread.\n          <\/jats:p>","DOI":"10.1128\/aac.47.8.2572-2578.2003","type":"journal-article","created":{"date-parts":[[2003,7,23]],"date-time":"2003-07-23T19:24:32Z","timestamp":1058988272000},"page":"2572-2578","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Extended-Spectrum \u03b2-Lactamases in Ireland, Including a Novel Enzyme, TEM-102"],"prefix":"10.1128","volume":"47","author":[{"given":"Dearbha\u0301ile","family":"Morris","sequence":"first","affiliation":[{"name":"Department of Bacteriology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colette","family":"O'Hare","sequence":"additional","affiliation":[{"name":"Department of Bacteriology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maura","family":"Glennon","sequence":"additional","affiliation":[{"name":"National Diagnostics Centre, National University of Ireland, Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majella","family":"Maher","sequence":"additional","affiliation":[{"name":"National Diagnostics Centre, National University of Ireland, Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geraldine","family":"Corbett-Feeney","sequence":"additional","affiliation":[{"name":"Department of Bacteriology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Cormican","sequence":"additional","affiliation":[{"name":"Department of Bacteriology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2760269"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.33.1.63"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1.1.51"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01644127"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.11.3061-3068.2000"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.4.933-951.2001"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.6.1211"},{"key":"e_1_3_2_9_2","first-page":"2592","volume":"35","year":"1997","unstructured":"Coudron, P. 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