{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:57:15Z","timestamp":1761893835145},"reference-count":22,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2003,8,1]],"date-time":"2003-08-01T00:00:00Z","timestamp":1059696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The efficacy of linezolid, alone or in combination with rifampin, against methicillin-susceptible\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            in rabbits with experimental endocarditis was investigated. Linezolid (50 or 75 mg\/kg of body weight), rifampin, and linezolid (25, 50, or 75 mg\/kg) plus rifampin produced statistically significant reductions in bacterial counts compared with those in untreated controls. Plasma or valvular vegetation levels of linezolid in the groups treated with the linezolid-rifampin combination were similar to those in the respective linezolid-only treatment groups. At therapeutic levels of linezolid, rifampin resistance was not observed. The results from this experimental model of endocarditis suggest that while rifampin did not provide synergy to the linezolid dosing, it did not antagonize the efficacy of linezolid.\n          <\/jats:p>","DOI":"10.1128\/aac.47.8.2655-2658.2003","type":"journal-article","created":{"date-parts":[[2003,7,23]],"date-time":"2003-07-23T19:24:32Z","timestamp":1058988272000},"page":"2655-2658","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":27,"title":["Efficacy of Linezolid plus Rifampin in an Experimental Model of Methicillin-Susceptible\n            <i>Staphylococcus aureus<\/i>\n            Endocarditis"],"prefix":"10.1128","volume":"47","author":[{"given":"Charlene F.","family":"Dailey","sequence":"first","affiliation":[{"name":"Pharmacology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Pagano","sequence":"additional","affiliation":[{"name":"Pharmacology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lewis V.","family":"Buchanan","sequence":"additional","affiliation":[{"name":"Pharmacology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer A.","family":"Paquette","sequence":"additional","affiliation":[{"name":"Pharmacology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph V.","family":"Haas","sequence":"additional","affiliation":[{"name":"Non-Clinical Statistics, Pfizer, Kalamazoo, Michigan 49001"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John K.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Pharmacology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1086\/319986","volume":"32","year":"2001","unstructured":"Babcock, H. M., D. J. Ritchie, E. Christiansen, R. Starlin, R. Little, and S. Stanley. 2001. Successful treatment of vancomycin-resistant Enterococcus endocarditis with oral linezolid. Clin. Infect. Dis.32:1373-1375.","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/151.1.157"},{"key":"e_1_3_2_4_2","first-page":"42.","volume":"27","year":"1999","unstructured":"Birmingham, M. C., R. R. Craig, B. Hafkin, W. M. Todd, S. M. Flavin, J. D. Root, G. S. Zimmer, D. H. Batts, and J. J. Schentag. 1999. Critical care patients with significant, resistant, gram-positive infections enrolled in the linezolid compassionate use protocol. Crit. Care Med.27(Suppl. S):42.","journal-title":"Crit. Care Med."},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1093\/infdis\/171.4.897","volume":"171","year":"1995","unstructured":"Chambers, H. F., M. Kartalija, and M. Sande. 1995. Ampicillin, sulbactam, and rifampin combination treatment of experimental methicillin-resistant Staphylococcus aureus endocarditis in rabbits. J. Infect. Dis.171:897-902.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.11.2742"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.8.2304-2308.2001"},{"key":"e_1_3_2_8_2","first-page":"44","volume":"53","year":"1972","unstructured":"Durack, D. T., and P. B. Beeson. 1972. Experimental bacterial endocarditis. I. Colonization of a sterile vegetation. Br. J. Exp. Pathol.53:44-49.","journal-title":"Br. J. Exp. Pathol."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.6.1014"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1001\/archinte.1985.00360010188034","volume":"145","year":"1985","unstructured":"Eng, R. H., S. M. Smith, M. Tillem, and C. Cherubin. 1985. Rifampin resistance. Development during the therapy of methicillin-resistant Staphylococcus aureus infection. Arch. Intern. Med.145:146-148.","journal-title":"Arch. Intern. Med."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.6.1508"},{"key":"e_1_3_2_12_2","unstructured":"Institute of Laboratory Animal Resources. 1996. Guide for the care and use of laboratory animals. National Academy of Sciences Washington D.C."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.10.2428"},{"key":"e_1_3_2_14_2","unstructured":"National Committee for Clinical Laboratory Standards. 2000. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. M7-A5. 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Xenobiotica32:907-924.","journal-title":"Xenobiotica"},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1097\/00007611-198105000-00028","volume":"74","year":"1981","unstructured":"Tofte, R. W., and J. Solliday. 1981. Staphylococcus aureus infection of dialysis shunt: absence of synergy with vancomycin and rifampin. South. Med. J.74:612-615.","journal-title":"South. Med. 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