{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:03:36Z","timestamp":1791655416876,"version":"4.3.4"},"reference-count":28,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2003,8,1]],"date-time":"2003-08-01T00:00:00Z","timestamp":1059696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Escherichia hermannii<\/jats:italic>\n            showed a low level of resistance to amoxicillin and ticarcillin, reversed by clavulanate, and a moderate susceptibility to piperacillin but was susceptible to all cephalosporins. A\n            <jats:italic>bla<\/jats:italic>\n            gene was cloned and encoded a typical class A \u03b2-lactamase (HER-1, pI 7.5), which shares 45, 44, 41, and 40% amino acid identity with other \u03b2-lactamases, AER-1 from\n            <jats:italic>Aeromonas hydrophila<\/jats:italic>\n            , MAL-1\/Cko-1 from\n            <jats:italic>Citrobacter koseri<\/jats:italic>\n            , and TEM-1 and LEN-1, respectively. No\n            <jats:italic>ampR<\/jats:italic>\n            gene was detected. Only penicillins were efficiently hydrolyzed, and no hydrolysis was observed for cefuroxime and broad-spectrum cephalosporins. Sequencing of the\n            <jats:italic>bla<\/jats:italic>\n            gene in 12 other strains showed 98 to 100% identity with\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>HER-1<\/jats:sub>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.47.8.2669-2673.2003","type":"journal-article","created":{"date-parts":[[2003,7,23]],"date-time":"2003-07-23T19:24:32Z","timestamp":1058988272000},"page":"2669-2673","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["Molecular and Biochemical Characterization of a Novel Class A \u03b2-Lactamase (HER-1) from\n            <i>Escherichia hermannii<\/i>"],"prefix":"10.1128","volume":"47","author":[{"given":"Anne","family":"Beauchef-Havard","sequence":"first","affiliation":[{"name":"Service de Bacte\u0301riologie, Ho\u0302pital Cochin, AP-HP"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Arlet","sequence":"additional","affiliation":[{"name":"Service de Bacte\u0301riologie, Ho\u0302pital Tenon, AP-HP"},{"name":"EA 2392, UFR Saint-Antoine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Gautier","sequence":"additional","affiliation":[{"name":"EA 2392, UFR Saint-Antoine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Labia","sequence":"additional","affiliation":[{"name":"CNRS-UBO-MHN, Unite\u0301 FRE 2125, Quimper, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Grimont","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Ente\u0301robacte\u0301ries, INSERM U389, Institut Pasteur, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Philippon","sequence":"additional","affiliation":[{"name":"Service de Bacte\u0301riologie, Ho\u0302pital Cochin, AP-HP"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2760269"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.10.2965-2968.2001"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/7.6.1513"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.15.4.703-713.1982"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.6.1211"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4838(97)00127-1"},{"key":"e_1_3_1_8_2","unstructured":"Clowes R. 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