{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:15:37Z","timestamp":1792653337582,"version":"4.5.0"},"reference-count":33,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2003,9,1]],"date-time":"2003-09-01T00:00:00Z","timestamp":1062374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    AcrAB exports some \u03b2-lactam antibiotics in the periplasm out of cells via an outer-membrane channel, TolC. It has been reported that eight drug transporters in\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    cooperate with TolC. In this study, the roles of the drug exporters of\n                    <jats:italic>E. coli<\/jats:italic>\n                    in \u03b2-lactam resistance were examined. We found that five of five resistance-nodulation-cell division-type drug exporters confer \u03b2-lactam antibiotic resistance, while no other drug exporters confer any \u03b2-lactam resistance even when they cooperate with TolC.\n                  <\/jats:p>","DOI":"10.1128\/aac.47.9.3030-3033.2003","type":"journal-article","created":{"date-parts":[[2003,8,22]],"date-time":"2003-08-22T17:07:12Z","timestamp":1061572032000},"page":"3030-3033","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":138,"title":["Roles of TolC-Dependent Multidrug Transporters of\n                    <i>Escherichia coli<\/i>\n                    in Resistance to \u03b2-Lactams"],"prefix":"10.1128","volume":"47","author":[{"given":"Kunihiko","family":"Nishino","sequence":"first","affiliation":[{"name":"Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki"},{"name":"CREST, Japan Science and Technology Corporation, Osaka 567-0047"},{"name":"Faculty of Pharmaceutical Science"},{"name":"Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki"},{"name":"CREST, Japan Science and Technology Corporation, Osaka 567-0047"},{"name":"Faculty of Pharmaceutical Science"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetada","family":"Hirakawa","sequence":"additional","affiliation":[{"name":"Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki"},{"name":"CREST, Japan Science and Technology Corporation, Osaka 567-0047"},{"name":"Faculty of Pharmaceutical Science"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki"},{"name":"CREST, Japan Science and Technology Corporation, Osaka 567-0047"},{"name":"Faculty of Pharmaceutical Science"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihito","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki"},{"name":"CREST, Japan Science and Technology Corporation, Osaka 567-0047"},{"name":"Faculty of Pharmaceutical Science"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01162.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.179.7.2274-2280.1997"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.23.6490-6499.2002"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.178.19.5803-5805.1996"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.66.4.671-701.2002"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.6.1851-1856.2003"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.8.2646-2653.2001"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.19.5639-5644.2001"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/35016007"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.19.8938"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1202-1210"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1995.tb02390.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0966-842X(94)90654-8"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.5.1387-1390.2000"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.7.1778"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01050"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.15.4161-4167.2002"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.178.20.5853-5859.1996"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8153625"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.180.17.4686-4692.1998"},{"key":"e_1_3_2_22_2","first-page":"215","volume":"3","year":"2001","unstructured":"Nikaido, H., and H. 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