{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:07:07Z","timestamp":1766268427544},"reference-count":19,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The activity of tigecycline was tested against erythromycin-resistant streptococci (107\n            <jats:italic>Streptococcus pyogenes<\/jats:italic>\n            and 98\n            <jats:italic>Streptococcus agalactiae<\/jats:italic>\n            strains). The presence of erythromycin and tetracycline resistance genes was determined by PCR. Among\n            <jats:italic>S. pyogenes<\/jats:italic>\n            strains the most prevalent gene was\n            <jats:italic>mef<\/jats:italic>\n            (A) (91.6%). The\n            <jats:italic>erm<\/jats:italic>\n            (B) gene was the most prevalent (65.3%) among\n            <jats:italic>S. agalactiae<\/jats:italic>\n            strains. Tigecycline proved to be very active against all the isolates tested (MIC at which 90% of the isolates tested were inhibited, 0.06 \u03bcg\/ml), including those resistant to tetracycline.\n          <\/jats:p>","DOI":"10.1128\/aac.48.1.323-325.2004","type":"journal-article","created":{"date-parts":[[2003,12,24]],"date-time":"2003-12-24T02:03:22Z","timestamp":1072231402000},"page":"323-325","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":48,"title":["In Vitro Activities of Tigecycline against Erythromycin-Resistant\n            <i>Streptococcus pyogenes<\/i>\n            and\n            <i>Streptococcus agalactiae<\/i>\n            : Mechanisms of Macrolide and Tetracycline Resistance"],"prefix":"10.1128","volume":"48","author":[{"given":"C.","family":"Betriu","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology, Hospital Cli\u0301nico San Carlos, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Culebras","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Hospital Cli\u0301nico San Carlos, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Rodri\u0301guez-Avial","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Hospital Cli\u0301nico San Carlos, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Go\u0301mez","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Hospital Cli\u0301nico San Carlos, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. A.","family":"Sa\u0301nchez","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Hospital Cli\u0301nico San Carlos, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"Picazo","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Hospital Cli\u0301nico San Carlos, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(98)00155-2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.3.1112-1114.2003"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1093\/jac\/dkf149","volume":"50","year":"2002","unstructured":"Betriu, C., E. Culebras, M. Redondo, I. Rodr\u00edguez-Avial, M. G\u00f3mez, A. Boloix, and J. J. Picazo. 2002. Prevalence of macrolide and tetracycline resistance mechanisms in Streptococcus pyogenes isolates and in vitro susceptibility to telithromycin. J. Antimicrob. Chemother.50:436-438.","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.3.892-895.2002"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1086\/514908","volume":"27","year":"1998","unstructured":"Cornaglia, G., M. Ligozzi, A. Mazzariol, L. Masala, G. Lo Cascio, G. Orefici, R. Fontana, et al. 1998. Resistance of Streptococcus pyogenes to erythromycin and related antibiotics in Italy. Clin. Infect. Dis.27(Suppl. 1):S87-S92.","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.9.2144"},{"key":"e_1_3_2_8_2","first-page":"29","volume":"18","year":"2001","unstructured":"Deshpande, L. M., A. C. Gales, and R. N. Jones. 2001. GAR-936 (9-t-butylglycylamido-minocycline) susceptibility test development for streptococci, Haemophilus influenzae and Neisseria gonorrhoeae: preliminary guidelines and interpretive criteria. Int. J. Antimicrob. Agents18:29-35.","journal-title":"Int. J. Antimicrob. Agents"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(99)00092-9"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.6.1493"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.1.400-404.2003"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S0002-9378(99)70553-3","volume":"181","year":"1999","unstructured":"Morales, W. J., S. S. Dickey, P. Bornick, and D. V. Lim. 1999. Change in antibiotic resistance of group B Streptococcus: impact on intrapartum management. Am. J. Obstet. Gynecol.181:310-314.","journal-title":"Am. J. Obstet. Gynecol."},{"key":"e_1_3_2_13_2","unstructured":"National Committee for Clinical Laboratory Standards. 2000. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard M7-A5 vol. 20. National Committee for Clinical Laboratory Standards Wayne Pa."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.4.738"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.2.794-797.2003"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/32.6.885"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.11.2562"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/45.6.763"},{"key":"e_1_3_2_19_2","first-page":"52","volume":"20","year":"2001","unstructured":"Uh, Y., I. H. Jang, G. Y. Hwang, K. J. Yoon, and W. Song. 2001. Emerging erythromycin resistance among group B streptococci in Korea. Eur. J. Clin. Microbiol. Infect. 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