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As measured in micrograms per milliliter, activity was highest for cethromycin (MIC at which 90% of the tested isolates were inhibited [MIC<jats:sub>90<\/jats:sub>], 0.0019 \u03bcg\/ml) and telithromycin (MIC<jats:sub>90<\/jats:sub>, 0.0078 \u03bcg\/ml). Electron-microscope analysis and time-kill studies also supported enhanced effectiveness of both ketolides.<\/jats:p>","DOI":"10.1128\/aac.48.1.344-347.2004","type":"journal-article","created":{"date-parts":[[2003,12,24]],"date-time":"2003-12-24T02:03:22Z","timestamp":1072231402000},"page":"344-347","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["Comparison of In Vitro Activities of Ketolides, Macrolides, and an Azalide against the Spirochete<i>Borrelia burgdorferi<\/i>"],"prefix":"10.1128","volume":"48","author":[{"given":"Klaus-Peter","family":"Hunfeld","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology, University Hospital of Frankfurt, D-60596 Frankfurt\/Main"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A.","family":"Wichelhaus","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, University Hospital of Frankfurt, D-60596 Frankfurt\/Main"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Ro\u0308del","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, University Hospital of Frankfurt, D-60596 Frankfurt\/Main"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Acker","sequence":"additional","affiliation":[{"name":"Department of Biological Electron Microscopy, University of Bayreuth, D-95440 Bayreuth, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Brade","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, University Hospital of Frankfurt, D-60596 Frankfurt\/Main"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Kraiczy","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, University Hospital of Frankfurt, D-60596 Frankfurt\/Main"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"815","DOI":"10.2165\/00003495-200161060-00016","volume":"61","year":"2001","unstructured":"Balfour, J. 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