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Daptomycin was very efficacious in the treatment of experimental pneumococcal meningitis, producing a decrease of \u22121.20 \u00b1 0.32 \u0394log\n            <jats:sub>10<\/jats:sub>\n            CFU\/ml\u2009\u00b7\u2009h in the bacterial titer of\n            <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n            against a penicillin-resistant strain and of \u22120.97 \u00b1 0.32 \u0394log\n            <jats:sub>10<\/jats:sub>\n            CFU\/ml\u2009\u00b7\u2009h against a penicillin- and quinolone-resistant strain found in cerebrospinal fluid (CSF). For both strains, daptomycin was significantly superior to the standard regimen of a combination of ceftriaxone with vancomycin, sterilizing 9 of 10 CSF samples after 4 h. In vitro, daptomycin produced highly bactericidal activity in concentrations above the MIC.\n          <\/jats:p>","DOI":"10.1128\/aac.48.10.3928-3933.2004","type":"journal-article","created":{"date-parts":[[2004,9,23]],"date-time":"2004-09-23T19:02:50Z","timestamp":1095966170000},"page":"3928-3933","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":92,"title":["Daptomycin Is Highly Efficacious against Penicillin-Resistant and Penicillin- and Quinolone-Resistant Pneumococci in Experimental Meningitis"],"prefix":"10.1128","volume":"48","author":[{"given":"Philippe","family":"Cottagnoud","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Inselspital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Pfister","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Biopharmaceutical Sciences, University of California, San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Acosta","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Spital Bern-Ziegler, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Cottagnoud","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Spital Bern-Ziegler, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Flatz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Spital Bern-Ziegler, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Ku\u0308hn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Spital Bern-Ziegler, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Peter","family":"Mu\u0308ller","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Inselspital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Stucki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Inselspital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.11.3561-3566.2003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.6.1919-1922.2001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"118","DOI":"10.2307\/2684123","volume":"34","year":"1980","unstructured":"Beal, B., and L. 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