{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:17:37Z","timestamp":1790212657036,"version":"4.1.0"},"reference-count":16,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The MICs of 24 antimicrobials for 26<jats:italic>Leptospira<\/jats:italic>spp. serovars were determined using a broth microdilution technique. The MICs at which 90% of isolates tested were inhibited (MIC<jats:sub>90<\/jats:sub>s) of cefepime, imipenem-cilastatin, erythromycin, clarithromycin, and telithromycin were all \u22640.01 \u03bcg\/ml. The MIC<jats:sub>90<\/jats:sub>s of amoxicillin, aztreonam, cefdinir, chloramphenicol, and penicillin G were \u22653.13 \u03bcg\/ml. Many antimicrobials have excellent in vitro activity against<jats:italic>Leptospira<\/jats:italic>.<\/jats:p>","DOI":"10.1128\/aac.48.10.4002-4005.2004","type":"journal-article","created":{"date-parts":[[2004,9,23]],"date-time":"2004-09-23T19:02:50Z","timestamp":1095966170000},"page":"4002-4005","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":40,"title":["Determination of Susceptibilities of 26<i>Leptospira<\/i>sp. Serovars to 24 Antimicrobial Agents by a Broth Microdilution Technique"],"prefix":"10.1128","volume":"48","author":[{"given":"Clinton K.","family":"Murray","sequence":"first","affiliation":[{"name":"Infectious Disease Service, Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duane R.","family":"Hospenthal","sequence":"additional","affiliation":[{"name":"Infectious Disease Service, Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.30.6.835"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2460\/ajvr.1996.57.01.59","volume":"57","year":"1996","unstructured":"Alt, D. P., and C. A. Bolin. 1996. Preliminary evaluation of antimicrobial agents for treatment of Leptospira interrogans serovar pomona infection in hamsters and swine. Am. J. Vet. Res.57:59-62.","journal-title":"Am. J. Vet. Res."},{"key":"e_1_3_2_4_2","first-page":"425","volume":"261","year":"1986","unstructured":"Broughton, E. S., and L. E. Flack. 1986. The susceptibility of a strain of Leptospira interrogans serogroup icterohaemorrhagiae to amoxycillin, erythromycin, lincomycin, tetracycline, oxytetracycline and minocycline. Zentbl. Bakteriol. Mikrobiol. Hyg. Ser. A261:425-431.","journal-title":"Zentbl. Bakteriol. Mikrobiol. Hyg. Ser. A"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1988.39.388"},{"key":"e_1_3_2_6_2","first-page":"146","volume":"57","year":"1955","unstructured":"Faine, S., and W. J. Kaipainen. 1955. Erythromycin in experimental leptospirosis. J. Infect. Dis.57:146-151.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.8.2646-2648.2003"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-5-696"},{"key":"e_1_3_2_9_2","first-page":"193","volume":"24","year":"2001","unstructured":"Murgia, R., and M. Cinco. 2001. Sensitivity of Borrelia and Leptospira to quinupristin-dalfopristin (Synercid) in vitro.New Microbiol.24:193-196.","journal-title":"New Microbiol."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.5.1548-1552.2004"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.24.6.905"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/375226"},{"key":"e_1_3_2_13_2","first-page":"7","volume":"81","year":"1991","unstructured":"Prescott, J. 1991. Treatment of leptospirosis. Cornell Vet.81:7-12.","journal-title":"Cornell Vet."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.33.5.788"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.4.901"},{"key":"e_1_3_2_16_2","first-page":"433","volume":"1","year":"1988","unstructured":"Watt, G., L. P. Padre, M. L. Tuazon, C. Calubaquib, E. Santiago, C. P. Ranoa, and L. W. Laughlin. 1988. Placebo-controlled trial of intravenous penicillin for severe and late leptospirosis. Lancet1:433-435.","journal-title":"Lancet"},{"key":"e_1_3_2_17_2","first-page":"450","volume":"5","year":"1966","unstructured":"Yoshimori, R. N., H. S. Goldberg, and D. C. Blenden. 1966. Cephalothin in the treatment of experimental leptospirosis in hamsters. Antimicrob. Agents Chemother.5:450-452.","journal-title":"Antimicrob. Agents Chemother."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.48.10.4002-4005.2004","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.48.10.4002-4005.2004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T18:30:18Z","timestamp":1734546618000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.48.10.4002-4005.2004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["10.1128\/AAC.48.10.4002-4005.2004"],"URL":"https:\/\/doi.org\/10.1128\/aac.48.10.4002-4005.2004","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10]]},"assertion":[{"value":"2004-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-06-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}