{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T10:24:32Z","timestamp":1789208672658,"version":"build-2803163510"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We have evaluated the efficacy of voriconazole (VRC) in a systemic infection by\n            <jats:italic>Scedosporium apiospermum<\/jats:italic>\n            in immunodepressed guinea pigs. Animals were infected with two strains; one required a VRC MIC of 0.5 to 1 \u03bcg\/ml, common for this fungus, and the other required a high MIC (8 \u03bcg\/ml), unusual in this species. VRC prolonged survival and reduced fungal load in kidney and brain tissues of the animals infected with the first strain but was unable to prolong survival or to reduce fungal load in brain tissue for the latter strain.\n          <\/jats:p>","DOI":"10.1128\/aac.48.10.4009-4011.2004","type":"journal-article","created":{"date-parts":[[2004,9,23]],"date-time":"2004-09-23T19:02:50Z","timestamp":1095966170000},"page":"4009-4011","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":34,"title":["Correlation between In Vitro Susceptibility of\n            <i>Scedosporium apiospermum<\/i>\n            to Voriconazole and In Vivo Outcome of Scedosporiosis in Guinea Pigs"],"prefix":"10.1128","volume":"48","author":[{"given":"Javier","family":"Capilla","sequence":"first","affiliation":[{"name":"Unitat de Microbiologia Facultat de Medicina, Universitat Rovira i Virgili, Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Guarro","sequence":"additional","affiliation":[{"name":"Unitat de Microbiologia Facultat de Medicina, Universitat Rovira i Virgili, Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.12.3976-3978.2003"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.7.2151-2153.2001"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200209000-00001"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/45.5.673"},{"key":"e_1_3_1_6_2","first-page":"149","volume":"43","year":"1998","unstructured":"Cuenca-Estrella, M., B. Ruiz-Diez, J. V. Mart\u00ednez-Su\u00e1rez, A. Monz\u00f3n, and J. L. Rodr\u00edguez-Tudela. 1998. Comparative in-vitro activity of voriconazole (UK-109,496) and six other antifungal agents against clinical isolates of Scedosporium prolificans and Scedosporium apiospermum. J. Antimicrob. Chemother.43:149-151.","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010954803886"},{"key":"e_1_3_1_8_2","first-page":"408","volume":"7","year":"2003","unstructured":"Fort\u00fan, J., P. Mart\u00edn-D\u00e1vila, M. A. S\u00e1nchez, V. Pintado, M. E. Alvarez, A. S\u00e1nchez-Sousa, and S. Moreno. 2003. Voriconazole in the treatment of invasive mold infections in transplant recipients. Eur. J. Clin. Microbiol. Infect. Dis.7:408-413.","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"e_1_3_1_9_2","first-page":"242","volume":"7","year":"2002","unstructured":"Ghannoum, M. A., and D. M. Kuhn. 2002. Voriconazole\u2014better chances for patients with invasive mycoses. Eur. J. Med. Res.7:242-256.","journal-title":"Eur. J. Med. Res."},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.5.1436-1438.1998"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg261"},{"key":"e_1_3_1_12_2","first-page":"176","volume":"43","year":"1998","unstructured":"Horr\u00e9, R., and G. S. de Hoog. 1998. Primary cerebral infections by melanized fungi: a review. Stud. Mycol.43:176-193.","journal-title":"Stud. Mycol."},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/515015"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/377131"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkf103"},{"key":"e_1_3_1_16_2","first-page":"62","volume":"42","year":"2002","unstructured":"Meletiadis, J., J. F. Meis, J. W. Mouton, J. L. Rodr\u00edguez-Tudela, J. P. Donnelly, and P. E. Verweij. 2002. In vitro activities of new and conventional antifungal agents against clinical Scedosporium isolates. Antimicrob. Agents Chemother.42:62-68.","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/317496"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1086\/314042"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1086\/374557"},{"key":"e_1_3_1_20_2","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1086\/313817","volume":"30","year":"2000","unstructured":"Poza, G., J. Montotya, C. Redondo, J. Ruiz, N. Vila, J. L. Rodr\u00edguez-Tudela, A. Cer\u00f3n, and E. Simarro. 2000. Meningitis caused by Pseudallescheria boydii treated with voriconazole. Clin. Infect. Dis.30:981-982.","journal-title":"Clin. Infect. 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