{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:50:08Z","timestamp":1788267008716,"version":"build-2803163510"},"reference-count":30,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            A chloramphenicol-resistant strain of\n            <jats:italic>Salmonella enterica<\/jats:italic>\n            serovar Typhi was first noted in Korea in 1992, when a resistant isolate was detected in a returned traveler. Continued isolation of multidrug-resistant (MDR) strains thereafter in other settings prompted a retrospective analysis of laboratory records and phenotypic and genotypic analyses of 12 chloramphenicol-resistant isolates. Among these, one isolate was resistant only to chloramphenicol, and the other isolates were also resistant to ampicillin and co-trimoxazole. MDR was transferred by conjugation from 9 of the 11 isolates. PCR showed that all isolates had an incompatible group HI1 plasmid, and\n            <jats:italic>oriT<\/jats:italic>\n            was detected in 10 isolates, which included strains with an unsuccessful transfer of resistance. All of the ampicillin-resistant isolates had a \u03b2-lactamase band of pI 5.4 and\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>TEM<\/jats:sub>\n            alleles. A PCR amplicon from an isolate showed that the sequences were identical to those of\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>TEM-1<\/jats:sub>\n            , suggesting that all isolates had a TEM-1 \u03b2-lactamase. All isolates had class 1 integrons: 10 isolates had integrons of ca. 1.2 kb with\n            <jats:italic>dhfr7<\/jats:italic>\n            gene cassettes, and 1 isolate had an integron of ca. 2.3 kb with\n            <jats:italic>aacA4<\/jats:italic>\n            and\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>OXA-1<\/jats:sub>\n            -like gene cassettes. The pulsed-field gel electrophoresis patterns of 7 of 11 MDR isolates were identical and indistinguishable from those reported for isolates in India and Indonesia. In conclusion, some of the MDR strains in Korea are related to those in other Asian countries. Susceptibility testing became necessary for selection of antimicrobial agents for the optimal treatment of patients with the emergence of MDR\n            <jats:italic>Salmonella<\/jats:italic>\n            serovar Typhi in Korea.\n          <\/jats:p>","DOI":"10.1128\/aac.48.11.4130-4135.2004","type":"journal-article","created":{"date-parts":[[2004,10,25]],"date-time":"2004-10-25T18:09:00Z","timestamp":1098727740000},"page":"4130-4135","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["Emergence of Multidrug-Resistant\n            <i>Salmonella enterica<\/i>\n            Serovar Typhi in Korea"],"prefix":"10.1128","volume":"48","author":[{"given":"Kyungwon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine"},{"name":"Research Institute of Bacterial Resistance"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongeun","family":"Yong","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Hwa","family":"Yum","sequence":"additional","affiliation":[{"name":"Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Sik","family":"Lim","sequence":"additional","affiliation":[{"name":"Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Sook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bok Kwon","family":"Lee","sequence":"additional","affiliation":[{"name":"National Institute of Health, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunsop","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3109\/00365549709019040","volume":"29","year":"1997","unstructured":"Bahrmand, A. 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