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ESBL-producing<jats:italic>Salmonella enterica<\/jats:italic>serotype Isangi and<jats:italic>S. enterica<\/jats:italic>serotype Typhimurium strains have been noted in South Africa since 2001. A total of 160 consecutive isolates of<jats:italic>Salmonella<\/jats:italic>spp. were collected from 13 hospitals located in different cities in South Africa over a 5-month period from December 2002 to April 2003. All strains were screened for production of ESBLs by the double disk diffusion test and for AmpC production by assessing resistance to cefoxitin.<jats:italic>bla<\/jats:italic><jats:sub>SHV<\/jats:sub>,<jats:italic>bla<\/jats:italic><jats:sub>TEM<\/jats:sub>,<jats:italic>bla<\/jats:italic><jats:sub>CTX-M<\/jats:sub>, and<jats:italic>bla<\/jats:italic><jats:sub>CMY-2<\/jats:sub>were sought from all ESBL-positive and cefoxitin-resistant isolates. A total of 15.6% (25 of 160) isolates produced SHV or TEM ESBLs, and 1.9% (3 of 160) produced CMY-2. Nine<jats:italic>S. enterica<\/jats:italic>serotype Typhimurium, eight<jats:italic>S. enterica<\/jats:italic>serotype Isangi, and three<jats:italic>S. enterica<\/jats:italic>serotype Muenchen strains produced either TEM-63 or a derivative of TEM-63 designated TEM-131. Both TEM-63 and TEM-131 have an isoelectric point of 5.6, and their sequences have the following amino acid substitutions compared to the TEM-1 sequence: Leu21Phe, Glu104Lys, Arg164Ser, and Met182Thr. Additionally, TEM-131 has an Ala237Thr substitution. ESBL-producing<jats:italic>Salmonella<\/jats:italic>spp. have become a significant public health problem in South Africa with particular implications for the treatment of serious nontyphoidal<jats:italic>Salmonella<\/jats:italic>infections in children, for whom extended-spectrum cephalosporins were the preferred treatment.<\/jats:p>","DOI":"10.1128\/aac.48.11.4263-4270.2004","type":"journal-article","created":{"date-parts":[[2004,10,25]],"date-time":"2004-10-25T18:09:00Z","timestamp":1098727740000},"page":"4263-4270","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":88,"title":["Infections with Nontyphoidal<i>Salmonella<\/i>Species Producing TEM-63 or a Novel TEM Enzyme, TEM-131, in South Africa"],"prefix":"10.1128","volume":"48","author":[{"given":"Tersia","family":"Kruger","sequence":"first","affiliation":[{"name":"Enteric Diseases Reference Unit, National Institute for Communicable Diseases (NHLS), and University of the Witwatersrand, Johannesburg, Republic of South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dora","family":"Szabo","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen H.","family":"Keddy","sequence":"additional","affiliation":[{"name":"Enteric Diseases Reference Unit, National Institute for Communicable Diseases (NHLS), and University of the Witwatersrand, Johannesburg, Republic of South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Deeley","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane W.","family":"Marsh","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea M.","family":"Hujer","sequence":"additional","affiliation":[{"name":"Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Bonomo","sequence":"additional","affiliation":[{"name":"Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Paterson","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/49.1.169"},{"key":"e_1_3_2_3_2","first-page":"137","volume":"66","year":"2002","unstructured":"Allen, K. 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