{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:40:35Z","timestamp":1762864835233},"reference-count":34,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We examined factors associated with penicillinase production by nasal carriage\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            strains in 648 children aged 3 to 6 years attending 20 randomly sampled playschools. The children were prospectively monitored for drug use and medical events for 6 months and were then screened for\n            <jats:italic>S. aureus<\/jats:italic>\n            carriage. Isolates were tested for their susceptibility to penicillin G and methicillin, and penicillinase production by methicillin-susceptible, penicillin-resistant strains was quantified.\n            <jats:italic>S. aureus<\/jats:italic>\n            was isolated from 166 children (25.6%). Exposure to amoxicillin-clavulanate during the previous 3 months was associated with higher penicillinase production by penicillin-resistant, methicillin-susceptible strains (odds ratio, 3.6;\n            <jats:italic>P<\/jats:italic>\n            = 0.03). These results suggest that use of the amoxicillin-clavulanate combination could induce a herd selection process of\n            <jats:italic>S. aureus<\/jats:italic>\n            strains producing higher levels of penicillinase.\n          <\/jats:p>","DOI":"10.1128\/aac.48.12.4618-4623.2004","type":"journal-article","created":{"date-parts":[[2004,11,24]],"date-time":"2004-11-24T03:00:46Z","timestamp":1101265246000},"page":"4618-4623","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["Amoxicillin-Clavulanate Therapy Increases Childhood Nasal Colonization by Methicillin-Susceptible\n            <i>Staphylococcus aureus<\/i>\n            Strains Producing High Levels of Penicillinase"],"prefix":"10.1128","volume":"48","author":[{"given":"Didier","family":"Guillemot","sequence":"first","affiliation":[{"name":"Institut Pasteur"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephane","family":"Bonacorsi","sequence":"additional","affiliation":[{"name":"Laboratoire d'E\u0301tudes de Ge\u0301ne\u0301tique Bacte\u0301rienne dans les Infections de l'Enfant (EA3105), Universite\u0301 Denis Diderot\u2014Paris 7, Ho\u0302pital Robert-Debre\u0301 (AP-HP)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John S.","family":"Blanchard","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Agents Antibacte\u0301riens"},{"name":"Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Weber","sequence":"additional","affiliation":[{"name":"BIOVSM, Vaires sur Marne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Simon","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, EMI 9933, INSERM, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Guesnon","sequence":"additional","affiliation":[{"name":"Laboratoire d'E\u0301tudes de Ge\u0301ne\u0301tique Bacte\u0301rienne dans les Infections de l'Enfant (EA3105), Universite\u0301 Denis Diderot\u2014Paris 7, Ho\u0302pital Robert-Debre\u0301 (AP-HP)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edouard","family":"Bingen","sequence":"additional","affiliation":[{"name":"Laboratoire d'E\u0301tudes de Ge\u0301ne\u0301tique Bacte\u0301rienne dans les Infections de l'Enfant (EA3105), Universite\u0301 Denis Diderot\u2014Paris 7, Ho\u0302pital Robert-Debre\u0301 (AP-HP)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Carbon","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, EMI 9933, INSERM, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1017\/S0950268801005416","volume":"126","year":"2001","unstructured":"Abudu, L., I. Blair, A. Fraise, and K. K. Cheng. 2001. Methicillin-resistant Staphylococcus aureus (MRSA): a community-based prevalence survey. Epidemiol. Infect.126:351-356.","journal-title":"Epidemiol. Infect."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.35.10.1975"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/jac\/6.3.333","volume":"6","year":"1980","unstructured":"Basker, M. J., R. A. Edmondson, and R. Sutherland. 1980. Comparative stabilities of penicillins and cephalosporins to staphylococcal beta-lactamase and activities against Staphylococcus aureus. J. Antimicrob. Chemother.6:333-341.","journal-title":"J. Antimicrob. 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