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Due to previous work linking CSP to stress phenotypes, we set up an in vivo sepsis model to assay its effect on virulence. Our data demonstrate a significant increase in the rates of survival of mice, reductions of blood\n            <jats:italic>S. pneumoniae<\/jats:italic>\n            counts, and prolonged times to death for mice treated with CSP. In vitro the dose of CSP used in the animal model produced a transitory inhibition of growth. When a mutant with a mutation in the CSP sensor histidine kinase was assayed, no bacteriostatic phenotype was detected in vitro and no change in disease outcome was observed in vivo. The data demonstrate that CSP, which induces in vitro a temporary growth arrest through stimulation of its cognate histidine kinase receptor, is able to block systemic disease in mice. This therapeutic effect is novel, in that the drug-like effect is obtained by stimulation, rather than inhibition, of a bacterial drug target.\n          <\/jats:p>","DOI":"10.1128\/aac.48.12.4725-4732.2004","type":"journal-article","created":{"date-parts":[[2004,11,24]],"date-time":"2004-11-24T03:00:46Z","timestamp":1101265246000},"page":"4725-4732","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":54,"title":["Antibacterial Activity of a Competence-Stimulating Peptide in Experimental Sepsis Caused by\n            <i>Streptococcus pneumoniae<\/i>"],"prefix":"10.1128","volume":"48","author":[{"given":"Marco R.","family":"Oggioni","sequence":"first","affiliation":[{"name":"Laboratorio di Microbiologia Molecolare e Biotecnologia, Dipartimento di Biologia Molecolare, Universita\u0300 di Siena"},{"name":"UOC Batteriologia, Azienda Ospedaliera Universitaria Senese, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Iannelli","sequence":"additional","affiliation":[{"name":"Laboratorio di Microbiologia Molecolare e Biotecnologia, Dipartimento di Biologia Molecolare, Universita\u0300 di Siena"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Ricci","sequence":"additional","affiliation":[{"name":"Laboratorio di Microbiologia Molecolare e Biotecnologia, Dipartimento di Biologia Molecolare, Universita\u0300 di Siena"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damiana","family":"Chiavolini","sequence":"additional","affiliation":[{"name":"Laboratorio di Microbiologia Molecolare e Biotecnologia, Dipartimento di Biologia Molecolare, Universita\u0300 di Siena"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Parigi","sequence":"additional","affiliation":[{"name":"Laboratorio di Microbiologia Molecolare e Biotecnologia, Dipartimento di Biologia Molecolare, Universita\u0300 di Siena"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Trappetti","sequence":"additional","affiliation":[{"name":"Laboratorio di Microbiologia Molecolare e Biotecnologia, Dipartimento di Biologia Molecolare, Universita\u0300 di Siena"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Claverys","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie et de Ge\u0301ne\u0301tique Mole\u0301culaires, UMR5100 CNRS-Universite\u0301 Paul Sabatier, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Pozzi","sequence":"additional","affiliation":[{"name":"Laboratorio di Microbiologia Molecolare e Biotecnologia, Dipartimento di Biologia Molecolare, Universita\u0300 di Siena"},{"name":"UOC Batteriologia, Azienda Ospedaliera Universitaria Senese, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/21.2.345"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-1-1"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.79.2.137"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2001.02218.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.8.4405-4413.2003"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(83)96980-3"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.60.1.111-116.1992"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/172.1.119"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-3-14"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.2741\/claverys"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(03)00064-7"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1136\/bmj.326.7397.996","volume":"326","year":"2003","unstructured":"Cohen, J. 2003. 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