{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:11:13Z","timestamp":1790759473556,"version":"4.1.0"},"reference-count":20,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Twenty-five plasmid-specified antimicrobial resistance determinants common to gram-negative bacilli from nosocomial infection were investigated from 31\n                    <jats:italic>Stenotrophomonas maltophilia<\/jats:italic>\n                    isolates. Twenty-four clones were identified by pulsed-field gel electrophoresis, and in three clones that exhibited an increased trimethoprim-sulfamethoxazole MIC, the\n                    <jats:italic>sul1<\/jats:italic>\n                    determinant was found. These results support not only the higher spread of class 1 integrons compared to other mechanisms but also the potential limitation of using trimethoprim-sulfamethoxazole for therapy of severe\n                    <jats:italic>S. maltophilia<\/jats:italic>\n                    infections.\n                  <\/jats:p>","DOI":"10.1128\/aac.48.2.666-669.2004","type":"journal-article","created":{"date-parts":[[2004,1,24]],"date-time":"2004-01-24T18:46:39Z","timestamp":1074969999000},"page":"666-669","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":86,"title":["Class 1 Integrons Increase Trimethoprim-Sulfamethoxazole MICs against Epidemiologically Unrelated\n                    <i>Stenotrophomonas maltophilia<\/i>\n                    Isolates"],"prefix":"10.1128","volume":"48","author":[{"given":"Raquel","family":"Barbolla","sequence":"first","affiliation":[{"name":"Departamento de Microbiologi\u0301a, Parasitologi\u0301a e Inmunologi\u0301a, Facultad de Medicina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Catalano","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologi\u0301a, Parasitologi\u0301a e Inmunologi\u0301a, Facultad de Medicina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betina E.","family":"Orman","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologi\u0301a, Parasitologi\u0301a e Inmunologi\u0301a, Facultad de Medicina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Famiglietti","sequence":"additional","affiliation":[{"name":"Laboratorio de Bacteriologi\u0301a, Departamento de Ana\u0301lisis Cli\u0301nicos, Hospital de Cli\u0301nicas, Facultad de Farmacia y Bioqui\u0301mica, Universidad de Buenos Aires"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Vay","sequence":"additional","affiliation":[{"name":"Laboratorio de Bacteriologi\u0301a, Departamento de Ana\u0301lisis Cli\u0301nicos, Hospital de Cli\u0301nicas, Facultad de Farmacia y Bioqui\u0301mica, Universidad de Buenos Aires"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorgelina","family":"Smayevsky","sequence":"additional","affiliation":[{"name":"Centro de Educacio\u0301n Me\u0301dica e Investigaciones Cli\u0301nicas (CEMIC), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Centro\u0301n","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologi\u0301a, Parasitologi\u0301a e Inmunologi\u0301a, Facultad de Medicina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia A.","family":"Pin\u0303eiro","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologi\u0301a, Parasitologi\u0301a e Inmunologi\u0301a, Facultad de Medicina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"1140","volume":"41","year":"2000","unstructured":"Alonso, A., P. 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