{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:07:21Z","timestamp":1789556841235,"version":"build-2803163510"},"reference-count":39,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            In Mexico mycetomas are mostly produced by\n            <jats:italic>Nocardia brasiliensis<\/jats:italic>\n            , which can be isolated from about 86% of cases. In the present work, we determined the sensitivities of 30\n            <jats:italic>N. brasiliensis<\/jats:italic>\n            strains isolated from patients with mycetoma to several groups of antimicrobials. As a first screening step we carried out disk diffusion assays with 44 antimicrobials, including aminoglycosides, cephalosporins, penicillins, quinolones, macrolides, and some others. In these assays we observed that some antimicrobials have an effect on more than 66% of the strains: linezolid, amikacin, gentamicin, isepamicin, netilmicin, tobramycin, minocycline, amoxicillin-clavulanic acid, piperacillin-tazobactam, nitroxolin, and spiramycin. Drug activity was confirmed quantitatively by the broth microdilution method. Amoxicillin-clavulanic acid, linezolid, and amikacin, which have been used to treat patients, were tested in an experimental model of mycetoma in BALB\/c mice in order to validate the in vitro results. Linezolid showed the highest activity in vivo, followed by the combination amoxicillin-clavulanic acid and amikacin.\n          <\/jats:p>","DOI":"10.1128\/aac.48.3.832-837.2004","type":"journal-article","created":{"date-parts":[[2004,2,24]],"date-time":"2004-02-24T17:53:08Z","timestamp":1077645188000},"page":"832-837","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":55,"title":["In Vitro and In Vivo Activities of Antimicrobials against\n            <i>Nocardia brasiliensis<\/i>"],"prefix":"10.1128","volume":"48","author":[{"given":"Alejandra","family":"Gomez-Flores","sequence":"first","affiliation":[{"name":"Servicio de Dermatologi\u0301a, Hospital Universitario \u201cJose\u0301 E. Gonza\u0301lez,\u201d"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliverio","family":"Welsh","sequence":"additional","affiliation":[{"name":"Servicio de Dermatologi\u0301a, Hospital Universitario \u201cJose\u0301 E. Gonza\u0301lez,\u201d"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Said-Ferna\u0301ndez","sequence":"additional","affiliation":[{"name":"Centro de Investigacio\u0301n Biome\u0301dica del Noreste, IMSS, Monterrey, N.L., Me\u0301xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Lozano-Garza","sequence":"additional","affiliation":[{"name":"Centro de Investigacio\u0301n Biome\u0301dica del Noreste, IMSS, Monterrey, N.L., Me\u0301xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman Erick","family":"Tavarez-Alejandro","sequence":"additional","affiliation":[{"name":"Servicio de Dermatologi\u0301a, Hospital Universitario \u201cJose\u0301 E. Gonza\u0301lez,\u201d"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio","family":"Vera-Cabrera","sequence":"additional","affiliation":[{"name":"Servicio de Dermatologi\u0301a, Hospital Universitario \u201cJose\u0301 E. 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