{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:49:26Z","timestamp":1791316166764,"version":"4.3.1"},"reference-count":40,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We analyzed 19 clinical isolates of the family\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            (16\n            <jats:italic>Escherichia coli<\/jats:italic>\n            isolates and 3\n            <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n            isolates) collected from four different hospitals in Paris, France, from 2000 to 2002. These strains had a particular extended-spectrum cephalosporin resistance profile characterized by a higher level of resistance to cefotaxime and aztreonam than to ceftazidime. The\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M<\/jats:sub>\n            genes encoding these \u03b2-lactamases were involved in this resistance, with a predominance of\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M-15<\/jats:sub>\n            . Ten of the 19 isolates produced both TEM-1- and CTX-M-type enzymes. One strain (\n            <jats:italic>E. coli<\/jats:italic>\n            TN13) expressed CMY-2, TEM-1, and CTX-M-14.\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M<\/jats:sub>\n            genes were found on large plasmids. In 15 cases the same insertion sequence, IS\n            <jats:italic>Ecp1<\/jats:italic>\n            , was located upstream of the 5\u2032 end of the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M<\/jats:sub>\n            gene. In one case we identified an insertion sequence designated IS\n            <jats:italic>26<\/jats:italic>\n            . Examination of the other three\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M<\/jats:sub>\n            genes by cloning, sequencing, and PCR analysis revealed the presence of a complex\n            <jats:italic>sul1<\/jats:italic>\n            -type integron that includes open reading frame ORF513, which carries the\n            <jats:italic>bla<\/jats:italic>\n            gene and the surrounding DNA. Five isolates had the same plasmid DNA fingerprint, suggesting clonal dissemination of CTX-M-15-producing strains in the Paris area.\n          <\/jats:p>","DOI":"10.1128\/aac.48.4.1249-1255.2004","type":"journal-article","created":{"date-parts":[[2004,3,26]],"date-time":"2004-03-26T20:18:01Z","timestamp":1080332281000},"page":"1249-1255","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":241,"title":["Dissemination of CTX-M-Type \u03b2-Lactamases among Clinical Isolates of\n            <i>Enterobacteriaceae<\/i>\n            in Paris, France"],"prefix":"10.1128","volume":"48","author":[{"given":"C.","family":"Eckert","sequence":"first","affiliation":[{"name":"Laboratoire de Bacte\u0301riologie, UPRES EA 2392, UFR Saint-Antoine, Universite\u0301 Paris VI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Gautier","sequence":"additional","affiliation":[{"name":"Laboratoire de Bacte\u0301riologie, UPRES EA 2392, UFR Saint-Antoine, Universite\u0301 Paris VI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Saladin-Allard","sequence":"additional","affiliation":[{"name":"Service de Biologie, Ho\u0302pital Robert Ballanger, Aulnay-sous-bois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Hidri","sequence":"additional","affiliation":[{"name":"Service de Microbiologie, Ho\u0302pital Louis Mourier, AP-HP, Colombes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Verdet","sequence":"additional","affiliation":[{"name":"Service de Bacte\u0301riologie-Hygie\u0300ne, Ho\u0302pital Tenon, AP-HP"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Ould-Hocine","sequence":"additional","affiliation":[{"name":"Service de Bacte\u0301riologie-Hygie\u0300ne, Ho\u0302pital Tenon, AP-HP"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Barnaud","sequence":"additional","affiliation":[{"name":"Service de Bacte\u0301riologie-Hygie\u0300ne, Ho\u0302pital Tenon, AP-HP"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Delisle","sequence":"additional","affiliation":[{"name":"Service de Bacte\u0301riologie-Hygie\u0300ne, Ho\u0302pital Tenon, AP-HP"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Rossier","sequence":"additional","affiliation":[{"name":"Service de Bacte\u0301riologie-Hygie\u0300ne, Ho\u0302pital Tenon, AP-HP"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Lambert","sequence":"additional","affiliation":[{"name":"Service de Bacte\u0301riologie, Ho\u0302pital Saint-Michel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Philippon","sequence":"additional","affiliation":[{"name":"Service de Bacte\u0301riologie, CHU Cochin, AP-HP, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Arlet","sequence":"additional","affiliation":[{"name":"Laboratoire de Bacte\u0301riologie, UPRES EA 2392, UFR Saint-Antoine, Universite\u0301 Paris VI"},{"name":"Service de Bacte\u0301riologie-Hygie\u0300ne, Ho\u0302pital Tenon, AP-HP"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3389"},{"key":"e_1_3_2_3_2","first-page":"321","volume":"289","year":"1980","unstructured":"Ambler, R. 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