{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:30:12Z","timestamp":1791354612412,"version":"4.3.1"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Doripenem (S-4661), a new parenteral carbapenem, was tested against over 250 clinical isolates, mutants, and transconjugants of\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            and\n            <jats:italic>Acinetobacter<\/jats:italic>\n            spp., selected or derived for their \u03b2-lactamase expression characteristics. Imipenem, meropenem, and ertapenem were tested as comparators, along with cephalosporins and piperacillin-tazobactam, by using National Committee for Clinical Laboratory Standards agar dilution methodology. Doripenem MICs were from 0.03 to 0.25 \u03bcg\/ml for\n            <jats:italic>Klebsiella<\/jats:italic>\n            isolates, irrespective of the presence of extended-spectrum \u03b2-lactamases (ESBLs) or plasmid-mediated AmpC or hyperproduced K1 \u03b2-lactamase. Similarly, MICs of doripenem for both AmpC-inducible and -derepressed\n            <jats:italic>Enterobacter<\/jats:italic>\n            isolates were 0.06 to 0.5 \u03bcg\/ml. ESBL production did not raise the MICs of doripenem for\n            <jats:italic>Escherichia coli<\/jats:italic>\n            transconjugants, and studies with known expression mutants confirmed that neither inducible nor depressed AmpC \u03b2-lactamase expression was protective in\n            <jats:italic>Enterobacter cloacae<\/jats:italic>\n            ,\n            <jats:italic>Citrobacter freundii<\/jats:italic>\n            ,\n            <jats:italic>Serratia marcescens<\/jats:italic>\n            , or\n            <jats:italic>Morganella morganii<\/jats:italic>\n            . In all of these respects, doripenem resembled meropenem and imipenem, whereas the MICs of ertapenem were raised (but still \u22641 \u03bcg\/ml) for many ESBL-producing klebsiellas and AmpC-derepressed\n            <jats:italic>E. cloacae<\/jats:italic>\n            and\n            <jats:italic>C. freundii<\/jats:italic>\n            strains. Resistance to all carbapenems, including doripenem (MICs of mostly 16 to 64 \u03bcg\/ml, compared with 0.25 to 1 \u03bcg\/ml for typical strains), was seen in\n            <jats:italic>Acinetobacter<\/jats:italic>\n            isolates with metallo-\u03b2-lactamases or OXA-carbapenemases. Isolates of\n            <jats:italic>Klebsiella<\/jats:italic>\n            and\n            <jats:italic>Serratia<\/jats:italic>\n            spp. with IMP, KPC, and SME \u03b2-lactamases also were resistant to doripenem (MICs, 8 to &gt;64 \u03bcg\/ml) and to other carbapenems, although the continued apparent susceptibility (MICs, \u22640.5 \u03bcg\/ml) of\n            <jats:italic>E. coli<\/jats:italic>\n            derivatives with cloned IMP-1 and NMC-A \u03b2-lactamases suggested that carbapenem resistance might require other factors besides the enzymes.\n          <\/jats:p>","DOI":"10.1128\/aac.48.4.1313-1319.2004","type":"journal-article","created":{"date-parts":[[2004,3,26]],"date-time":"2004-03-26T20:18:01Z","timestamp":1080332281000},"page":"1313-1319","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":71,"title":["Comparative Activities of Doripenem versus Isolates, Mutants, and Transconjugants of\n            <i>Enterobacteriaceae<\/i>\n            and\n            <i>Acinetobacter<\/i>\n            spp. with Characterized \u03b2-Lactamases"],"prefix":"10.1128","volume":"48","author":[{"given":"Shazad","family":"Mushtaq","sequence":"first","affiliation":[{"name":"Antibiotic Resistance Monitoring and Reference Laboratory, Specialist and Reference Microbiology Division, Health Protection Agency Colindale, London, NW9 5HT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yigong","family":"Ge","sequence":"additional","affiliation":[{"name":"Peninsula Pharmaceuticals, Inc., Alameda, California 94502"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Livermore","sequence":"additional","affiliation":[{"name":"Antibiotic Resistance Monitoring and Reference Laboratory, Specialist and Reference Microbiology Division, Health Protection Agency Colindale, London, NW9 5HT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.2.583-588.2001"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/45.2.183"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-8-585"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.3.710-714.2001"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.7.3403-3406.2003"},{"key":"e_1_3_1_7_2","first-page":"1","volume":"45","year":"2000","unstructured":"Edwards, J. 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Sefton and G. M. Scott. 2003. Properties and potential of ertapenem. J. Antimicrob Chemother. 52 : 331-344.","DOI":"10.1093\/jac\/dkg375"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.10.2831-2837.2001"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/38.3.409"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.12.4741-4743.2002"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.12.3322-3327.2000"},{"key":"e_1_3_1_17_2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/jac\/46.3.471","volume":"46","year":"2000","unstructured":"Mikamo, H., K. Izumi, Y. X. Hua, Y. Hayasaki, Y. Sato, and T. Tamaya. 2000. In vitro and in vivo antibacterial activities of a new injectable carbapenem, S-4661, against gynaecological pathogens. J. Antimicrob. Chemother.46:471-474.","journal-title":"J. Antimicrob. 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