{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T13:06:11Z","timestamp":1768482371706,"version":"3.49.0"},"reference-count":13,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The molecular characterization of five clinical isolates of\n            <jats:italic>vanA<\/jats:italic>\n            -containing vancomycin-resistant enterococci with altered resistance to glycopeptides was examined. One strain represented an IS\n            <jats:italic>1216V<\/jats:italic>\n            insertion accompanied by partial deletion of the reading frame of\n            <jats:italic>vanX<\/jats:italic>\n            following a transposition event. The other four strains represented IS\n            <jats:italic>1216V<\/jats:italic>\n            within the\n            <jats:italic>vanX<\/jats:italic>\n            -\n            <jats:italic>vanY<\/jats:italic>\n            intergenic region associated with deletion of\n            <jats:italic>vanY<\/jats:italic>\n            or\n            <jats:italic>vanZ<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.48.4.1379-1381.2004","type":"journal-article","created":{"date-parts":[[2004,3,26]],"date-time":"2004-03-26T20:18:01Z","timestamp":1080332281000},"page":"1379-1381","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":51,"title":["Reduction in Glycopeptide Resistance in Vancomycin-Resistant Enterococci as a Result of\n            <i>vanA<\/i>\n            Cluster Rearrangements"],"prefix":"10.1128","volume":"48","author":[{"given":"Wee Gyo","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Ajou University School of Medicine, Suwon, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Young","family":"Huh","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Ajou University School of Medicine, Suwon, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Ran","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Ajou University School of Medicine, Suwon, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Ae","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Ajou University School of Medicine, Suwon, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"15971","DOI":"10.1021\/bi001408b","volume":"39","year":"2000","unstructured":"Araoz, R., E. Anhalt, L. Rene, M. A. Badet-Denisot, P. Courvalin, and B. Badet. 2000. Mechanism-based inactivation of VanX, a d-alanyl-d-alanine dipeptidase necessary for vancomycin resistance. 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