{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T07:58:46Z","timestamp":1770969526192,"version":"3.50.1"},"reference-count":12,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The doripenem MICs at which 90% of the tested strains were inhibited ranged from 0.03 to 1 \u03bcg\/ml for 10 species of\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            (\n            <jats:italic>n<\/jats:italic>\n            = 351), from 0.03 to 0.12 \u03bcg\/ml for oxacillin-susceptible staphylococci (\n            <jats:italic>n<\/jats:italic>\n            = 119), from 4 to 32 \u03bcg\/ml for oxacillin-resistant staphylococci (\n            <jats:italic>n<\/jats:italic>\n            = 64), from \u22640.008 to 0.06 \u03bcg\/ml for penicillin-susceptible streptococci (\n            <jats:italic>n<\/jats:italic>\n            = 132), and from 1 to 4 \u03bcg\/ml for penicillin-resistant streptococci (\n            <jats:italic>n<\/jats:italic>\n            = 51). Overall, doripenem demonstrated in vitro activity similar to that of meropenem against gram-negative pathogens and to that of imipenem against gram-positive pathogens.\n          <\/jats:p>","DOI":"10.1128\/aac.48.4.1384-1396.2004","type":"journal-article","created":{"date-parts":[[2004,3,26]],"date-time":"2004-03-26T20:18:01Z","timestamp":1080332281000},"page":"1384-1396","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":72,"title":["In Vitro Antimicrobial Activity of Doripenem, a New Carbapenem"],"prefix":"10.1128","volume":"48","author":[{"given":"Yigong","family":"Ge","sequence":"first","affiliation":[{"name":"Peninsula Pharmaceuticals, Alameda, California 94502"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew A.","family":"Wikler","sequence":"additional","affiliation":[{"name":"Peninsula Pharmaceuticals, Alameda, California 94502"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel F.","family":"Sahm","sequence":"additional","affiliation":[{"name":"Focus Technologies, Herndon, Virginia 20171"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rene\u0301e S.","family":"Blosser-Middleton","sequence":"additional","affiliation":[{"name":"Focus Technologies, Herndon, Virginia 20171"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Karlowsky","sequence":"additional","affiliation":[{"name":"Focus Technologies, Herndon, Virginia 20171"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.7164\/antibiotics.49.199","volume":"49","year":"1996","unstructured":"Iso, Y., T. Irie, Y. Nishino, K. Motokawa, and Y. Nishitani. 1996. A novel 1\u03b2-methylcarbapenem antibiotic, S-4661: synthesis and structure-activity relationships of 2-(5 substituted pyrrolidin-3-ylthio)-1\u03b2-methylcarbapenems. J. Antibiot. (Tokyo)49:199-209.","journal-title":"J. Antibiot. (Tokyo)"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1093\/jac\/37.5.1034","volume":"37","year":"1996","unstructured":"Mori, M., M. Hikida, T. Nishihara, T. Nasu, and S. Mitsuhashi. 1996. Comparative stability of carbapenem and penem antibiotics to human recombinant dehydropeptidase-I. J. Antimicrob. Chemother.37:1034-1036.","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_2_4_2","unstructured":"Murray P. R. E. J. Baron J. H. Jorgensen M. A. Pfaller and R. H. Yolken (ed.). 2003. Manual of clinical microbiology 8th ed. ASM Press Washington D.C."},{"key":"e_1_3_2_5_2","unstructured":"National Committee for Clinical Laboratory Standards. 2003. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically 6th ed. Approved standard M7-A6. National Committee for Clinical Laboratory Standards Wayne Pa."},{"key":"e_1_3_2_6_2","unstructured":"National Committee for Clinical Laboratory Standards. 2003. Performance standards for antimicrobial susceptibility testing; thirteenth informational supplement vol. 23. M100-S13. National Committee for Clinical Laboratory Standards Wayne Pa."},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1179\/joc.2002.14.2.155","volume":"14","year":"2002","unstructured":"Nomura, S., and A. Nagayama. 2002. In vitro antibacterial activity of S-4661, a new parenteral carbapenem, against urological pathogens isolated from patients with complicated urinary tract infections. J. Chemother.14:155-160.","journal-title":"J. Chemother."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.2.298"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.35.1.203"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.1.94"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg042"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1159\/000007276","volume":"46","year":"2000","unstructured":"Watanabe, A., H. Takahashi, T. Kikuchi, T. Kobayashi, K. Gomi, S. Fujimura, Y. Tokue, and T. Nukiwa. 2000. Comparative in vitro activity of S-4661, a new parenteral carbapenem, and other antimicrobial agents against respiratory pathogens. Chemotherapy46:184-187.","journal-title":"Chemotherapy"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.3.555"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.48.4.1384-1396.2004","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.48.4.1384-1396.2004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T18:02:16Z","timestamp":1645466536000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.48.4.1384-1396.2004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["10.1128\/AAC.48.4.1384-1396.2004"],"URL":"https:\/\/doi.org\/10.1128\/aac.48.4.1384-1396.2004","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4]]},"assertion":[{"value":"2003-10-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2003-12-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}