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The effect of Fe was independent of superoxide dismutase activity and of intracellular Fe, but accumulation of tetracyclines was blocked in high-Fe medium. Thus, synergistic suppression of bacterial growth in the presence of a low Fe concentration and tetracyclines arises because of elevated antibiotic accumulation.<\/jats:p>","DOI":"10.1128\/aac.48.5.1892-1894.2004","type":"journal-article","created":{"date-parts":[[2004,4,22]],"date-time":"2004-04-22T19:58:16Z","timestamp":1082663896000},"page":"1892-1894","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Iron Blocks the Accumulation and Activity of Tetracyclines in Bacteria"],"prefix":"10.1128","volume":"48","author":[{"given":"Angela M.","family":"Avery","sequence":"first","affiliation":[{"name":"School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen J.","family":"Goddard","sequence":"additional","affiliation":[{"name":"School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward R.","family":"Sumner","sequence":"additional","affiliation":[{"name":"School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon V.","family":"Avery","sequence":"additional","affiliation":[{"name":"School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.3.5.645"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.10.2939-2942.2001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.1.76-80.2000"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1046\/j.1365-2672.1998.00428.x","volume":"84","year":"1998","unstructured":"Bechet, M., and R. 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