{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T19:12:33Z","timestamp":1784229153739,"version":"3.55.0"},"reference-count":17,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:00:00Z","timestamp":1086048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The possible reactivities of commonly used antibiotics of fungal, nonfungal, and nonmicrobial or synthetic sources with the Platelia\n            <jats:italic>Aspergillus<\/jats:italic>\n            galactomannan assay were assessed. For drugs that tested positive, the minimal concentration of the antibiotic in serum that yielded a positive test (index, &gt;0.5) was determined. At undiluted concentrations, piperacillin and multiple lots of piperacillin-tazobactam tested positive, whereas amoxicillin, ampicillin-sulbactam, nafcillin, cefazolin, ceftazidime, erythromycin, gentamicin, and levofloxacin tested negative. All three lots of piperacillin-tazobactam and all bags within each lot tested positive, with a mean index value of 5.168. At achievable concentrations in serum, however, only one of three lots of piperacillin-tazobactam yielded a positive test. Concentrations of 75, 150, and 300 \u03bcg\/ml of serum tested positive with the Platelia\n            <jats:italic>Aspergillus<\/jats:italic>\n            enzyme immunoassay, whereas lower concentrations, mimicking the trough levels, tested negative. Thus, while achievable serum piperacillin-tazobactam concentrations may potentially result in a positive test for galactomannan, the timing of the collection of serum samples from patients may influence the test results, with reactivity being less likely in samples collected at trough levels or prior to the administration of a dose of the antibiotic.\n          <\/jats:p>","DOI":"10.1128\/aac.48.6.1989-1992.2004","type":"journal-article","created":{"date-parts":[[2004,5,21]],"date-time":"2004-05-21T18:38:42Z","timestamp":1085164722000},"page":"1989-1992","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":70,"title":["Reactivity of Platelia\n            <i>Aspergillus<\/i>\n            Galactomannan Antigen with Piperacillin-Tazobactam: Clinical Implications Based on Achievable Concentrations in Serum"],"prefix":"10.1128","volume":"48","author":[{"given":"Nina","family":"Singh","sequence":"first","affiliation":[{"name":"Veterans Affairs Medical Center and"},{"name":"University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asia","family":"Obman","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahid","family":"Husain","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherrie","family":"Aspinall","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Mietzner","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet E.","family":"Stout","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/383148"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1997.tb00249.x"},{"key":"e_1_3_2_4_2","first-page":"266","volume":"10","year":"1929","unstructured":"Fleming, A. 1929. On the antibacterial action of cultures of a penicillin with special reference to their use in the isolation of B. influenzae.Br. J. Exp. Pathol.10:266.","journal-title":"influenzae."},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1053\/jlts.2002.36239","volume":"8","year":"2002","unstructured":"Fortun, J. P., P. Martin-Davila, S. Moreno, E. de Vicente, J. Nuno, A. Candelas, R. Barcena, and M. Garcia. 2002. Risk factors for invasive aspergillosis in liver transplant recipients. Liver Transpl.8:1065-1070.","journal-title":"Liver Transpl."},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1600-6143.2003.00323.x","volume":"4","year":"2004","unstructured":"Husain, S., E. J. Kwak, A. Obman, M. M. Wagener, S. Kusne, J. Stout, K. McCurry, and N. Singh. 2004. Prospective assessment of Platelia Aspergillus galactomannan for the diagnosis of invasive aspergillosis in lung transplant recipients. Am. J. Transplant.4:1-7.","journal-title":"Am. J. Transplant."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.1.435-438.2004"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.12.5424-5433.1994"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/343804"},{"key":"e_1_3_2_10_2","first-page":"850","year":"1999","unstructured":"Preston, S. L., and G. L. Drusano. 1999. Penicillins, p. 850-875. In V. L. Yu, T. C. Merrigan, and S. L. Barriere (ed.), Antimicrobial therapy and vaccines. Williams and Wilkins, Baltimore, Md.","journal-title":"Antimicrobial therapy and vaccines"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199603000-00011"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.33.2.497-500.1995"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200312113492424"},{"key":"e_1_3_2_14_2","first-page":"139","volume":"15","year":"2003","unstructured":"Sulahian, A., M. Tabouret, P. Ribaud, J. Sarfati, E. Gluckman, J. P. Latg\u00e9, and F. Derouin. 2003. Comparison of an enzyme immunoassay and latex agglutination test for detection of galactomannan in the diagnosis of invasive aspergillosis. Eur. J. Clin. Microbiol. Infect. Dis.15:139-145.","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.1.257-260.1997"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0021-9258(19)40104-X","volume":"265","year":"1990","unstructured":"Unkefer, C. J., and J. E. Gander. 1990. The 5-O-\u03b2-d-galactofuranosyl-containing peptidophosphogalactomannan of Penicillium charlesii. Characterization of the mannan by 13C NMR spectroscopy. J. Biol. Chem.265:685-689.","journal-title":"J. Biol. Chem."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.6.1612-1616.1998"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1086\/382224"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.48.6.1989-1992.2004","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.48.6.1989-1992.2004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T18:21:46Z","timestamp":1645467706000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.48.6.1989-1992.2004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["10.1128\/AAC.48.6.1989-1992.2004"],"URL":"https:\/\/doi.org\/10.1128\/aac.48.6.1989-1992.2004","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6]]},"assertion":[{"value":"2003-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-02-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}