{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:05:15Z","timestamp":1791331515163,"version":"4.3.1"},"reference-count":17,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:00:00Z","timestamp":1086048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The therapeutic efficacy of three lipid formulations of amphotericin B was compared with that of conventional amphotericin B in treatment of murine coccidioidomycosis. All treatments prolonged survival compared with the no-treatment group (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.0001). Although conventional amphotericin B was more active than lipid formulations on reducing quantitative fungal load on a milligram-per-kilogram basis (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.003 to 0.0002), the lipid preparations could be administered at higher doses, sterilizing liver and spleen tissues. The efficacies of the lipid preparations were similar in this murine model of coccidioidomycosis.\n          <\/jats:p>","DOI":"10.1128\/aac.48.6.2140-2143.2004","type":"journal-article","created":{"date-parts":[[2004,5,21]],"date-time":"2004-05-21T18:38:42Z","timestamp":1085164722000},"page":"2140-2143","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Efficacies of Amphotericin B (AMB) Lipid Complex, AMB Colloidal Dispersion, Liposomal AMB, and Conventional AMB in Treatment of Murine Coccidioidomycosis"],"prefix":"10.1128","volume":"48","author":[{"given":"Gloria M.","family":"Gonza\u0301lez","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases"},{"name":"Departamento de Microbiologi\u0301a, Facultad de Medicina, Universidad Auto\u0301noma de Nuevo Leo\u0301n, Monterrey, Nuevo Le\u0301on, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolando","family":"Tijerina","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologi\u0301a, Facultad de Medicina, Universidad Auto\u0301noma de Nuevo Leo\u0301n, Monterrey, Nuevo Le\u0301on, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura K.","family":"Najvar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosie","family":"Bocanegra","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Fungus Testing Laboratory, Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Graybill","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1080\/02681219480000621","volume":"32","year":"1994","unstructured":"Albert, M. 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