{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:51:40Z","timestamp":1792461100505,"version":"4.5.0"},"reference-count":14,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:00:00Z","timestamp":1086048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Transformation of a type I SCC\n            <jats:italic>mec<\/jats:italic>\n            element into\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            yielded highly oxacillin-resistant transformants with a reduced growth rate. Faster-growing variants could again be selected at the cost of reduced resistance levels, demonstrating an inverse correlation between oxacillin resistance levels and growth rate.\n          <\/jats:p>","DOI":"10.1128\/aac.48.6.2295-2297.2004","type":"journal-article","created":{"date-parts":[[2004,5,21]],"date-time":"2004-05-21T18:38:42Z","timestamp":1085164722000},"page":"2295-2297","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":147,"title":["Fitness Cost of SCC\n            <i>mec<\/i>\n            and Methicillin Resistance Levels in\n            <i>Staphylococcus aureus<\/i>"],"prefix":"10.1128","volume":"48","author":[{"given":"Miriam","family":"Ender","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, University of Zu\u0308rich, Zu\u0308rich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"McCallum","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University of Zu\u0308rich, Zu\u0308rich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajan","family":"Adhikari","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University of Zu\u0308rich, Zu\u0308rich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Berger-Ba\u0308chi","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University of Zu\u0308rich, Zu\u0308rich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(99)00005-3"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1983.tb00137.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1093\/infdis\/164.5.883","volume":"164","year":"1991","unstructured":"Figueiredo, A. M., E. Ha, B. N. Kreiswirth, H. de Lencastre, G. J. Noel, L. Senterfit, and A. Tomasz. 1991. In vivo stability of heterogeneous expression classes in clinical isolates of methicillin-resistant staphylococci. J. Infect. Dis.164:883-887.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.179.20.6294-6301.1997"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.5.1323-1336.2001"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002030050630"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.6.1549-1555.2000"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.18.5465-5472.2003"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.3.815-824.2001"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2001.02389.x"},{"key":"e_1_3_2_12_2","unstructured":"National Committee for Clinical Laboratory Standards. 2003. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard 6th ed. NCCLS document M7-A6. National Committee for Clinical Laboratory Standards Wayne Pa."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.11.4289-4294.2002"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.05176-0"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.4.724"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.48.6.2295-2297.2004","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.48.6.2295-2297.2004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T18:18:38Z","timestamp":1645467518000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.48.6.2295-2297.2004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["10.1128\/AAC.48.6.2295-2297.2004"],"URL":"https:\/\/doi.org\/10.1128\/aac.48.6.2295-2297.2004","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6]]},"assertion":[{"value":"2003-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-02-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}