{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:14:51Z","timestamp":1761128091686},"reference-count":12,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            A rise in invasive diseases due to\n            <jats:italic>Neisseria meningitidis<\/jats:italic>\n            C:2b:P1.5 with decreased penicillin susceptibility occurred in Italy during the last 2 years. Real-time PCR identified the Pen\n            <jats:sup>i<\/jats:sup>\n            phenotype, and the\n            <jats:italic>penA<\/jats:italic>\n            sequence revealed the mosaicism of the gene. Molecular analyses assigned the isolates to a single emergent clone of the hypervirulent A4 cluster.\n          <\/jats:p>","DOI":"10.1128\/aac.48.8.3103-3106.2004","type":"journal-article","created":{"date-parts":[[2004,7,23]],"date-time":"2004-07-23T18:45:20Z","timestamp":1090608320000},"page":"3103-3106","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Emergence in Italy of a\n            <i>Neisseria meningitidis<\/i>\n            Clone with Decreased Susceptibility to Penicillin"],"prefix":"10.1128","volume":"48","author":[{"given":"Paola","family":"Stefanelli","sequence":"first","affiliation":[{"name":"Department of Infectious, Parasitic and Immuno-Mediated Diseases, Istituto Superiore di Sanita', Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Fazio","sequence":"additional","affiliation":[{"name":"Department of Infectious, Parasitic and Immuno-Mediated Diseases, Istituto Superiore di Sanita', Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Neri","sequence":"additional","affiliation":[{"name":"Department of Infectious, Parasitic and Immuno-Mediated Diseases, Istituto Superiore di Sanita', Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonino","family":"Sofia","sequence":"additional","affiliation":[{"name":"Department of Infectious, Parasitic and Immuno-Mediated Diseases, Istituto Superiore di Sanita', Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Mastrantonio","sequence":"additional","affiliation":[{"name":"Department of Infectious, Parasitic and Immuno-Mediated Diseases, Istituto Superiore di Sanita', Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/47.3.285"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1099\/0022-1317-49-12-1079","volume":"49","year":"2000","unstructured":"Arreaza, L., S. 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