{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T01:59:44Z","timestamp":1788314384490,"version":"build-2803163510"},"reference-count":10,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The pharmacokinetics of intravenous itraconazole (ITC) was studied in dialysis patients. Dialysis had no effect on the half-life and clearance of ITC or OH-ITC. However, dialysis allowed the clearance of hydroxypropyl-\u03b2-cyclodextrin (HP-\u03b2-CD). The area under the concentration-time curve from time zero to infinity (AUC<jats:sub>0-\u221e<\/jats:sub>) for HP-\u03b2-CD administered before dialysis was lower than the AUC<jats:sub>0-\u221e<\/jats:sub>when it was administered after dialysis (<jats:italic>P<\/jats:italic>&lt; 0.01). Administration of ITC intravenously just prior to hemodialysis appears to produce adequate systemic exposures of ITC and OH-ITC while allowing dialysis clearance of HP-\u03b2-CD. Studies of multiple administrations are warranted.<\/jats:p>","DOI":"10.1128\/aac.48.8.3151-3153.2004","type":"journal-article","created":{"date-parts":[[2004,7,23]],"date-time":"2004-07-23T18:45:20Z","timestamp":1090608320000},"page":"3151-3153","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":31,"title":["Pharmacokinetics of Intravenous Itraconazole in Stable Hemodialysis Patients"],"prefix":"10.1128","volume":"48","author":[{"given":"John F.","family":"Mohr","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Center for the Study of Emerging and Re-emerging Pathogens"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin W.","family":"Finkel","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University of Texas Health Science Center, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Rex","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Center for the Study of Emerging and Re-emerging Pathogens"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose R.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Center for the Study of Emerging and Re-emerging Pathogens"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard J.","family":"Leitz","sequence":"additional","affiliation":[{"name":"Ortho-Biotech Products L.P., Bridgewater, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Ostrosky-Zeichner","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Center for the Study of Emerging and Re-emerging Pathogens"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.3.981-985.2001"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"585","DOI":"10.2165\/00003495-199651040-00006","volume":"51","year":"1996","unstructured":"Haria, M., H. M. Bryson, and K. L. Goa. 1996. Itraconazole. A reappraisal of its pharmacological properties and therapeutic use in the management of superficial fungal infections. Drugs51:585-620.","journal-title":"Drugs"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)83011-X"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","unstructured":"Szejtli J. 1988. Cyclodextrin technology. Kluwer Academic Publishers Dordrecht The Netherlands.","DOI":"10.1007\/978-94-015-7797-7"},{"key":"e_1_3_2_6_2","unstructured":"Szejtli J. 1982. Cyclodextrins and their inclusion complexes. Akademiai Kiado Budapest Hungary."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.12.2714"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2710.2001.00338.x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/0378-4347(87)80249-9","volume":"413","year":"1987","unstructured":"Woestenborghs, R., W. Lorreyne, and J. Heykants. 1987. Determination of itraconazole in plasma and animal tissues by high-performance liquid chromatography. J. Chromatogr.413:332-337.","journal-title":"J. Chromatogr."},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1177\/00912700122012904","volume":"41","year":"2001","unstructured":"Zhao, Q., H. Zhou, and L. Pesco-Koplowitz. 2001. Pharmacokinetics of intravenous itraconazole followed by itraconazole oral solution in patients with human immunodeficiency virus infection. J. Clin. Pharmacol.41:1319-1328.","journal-title":"J. Clin. Pharmacol."},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/j.1552-4604.1998.tb04465.x","volume":"38","year":"1998","unstructured":"Zhou, H., M. Goldman, J. Wu, R. Woestenborghs, A. E. Hassell, P. Lee, A. Baruch, L. Pesco-Koplowitz, J. Borum, and L. J. Wheat. 1998. A pharmacokinetic study of intravenous itraconazole followed by oral administration of itraconazole capsules in patients with advanced human immunodeficiency virus infection. J. Clin. Pharmacol.38:593-602.","journal-title":"J. Clin. 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