{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T13:47:55Z","timestamp":1778680075172,"version":"3.51.4"},"reference-count":16,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Four hundred sixty-two clinical isolates of\n            <jats:italic>Neisseria gonorrhoeae<\/jats:italic>\n            recovered from 1999 through 2002 in central Japan were examined for MICs of antimicrobial agents. The majority was sensitive to ceftriaxone and spectinomycin, but a remarkable increase in isolates with decreased susceptibility to penicillin, tetracycline, oral cephalosporins, and fluoroquinolones was observed from 2001 through 2002.\n          <\/jats:p>","DOI":"10.1128\/aac.48.8.3185-3187.2004","type":"journal-article","created":{"date-parts":[[2004,7,23]],"date-time":"2004-07-23T18:45:20Z","timestamp":1090608320000},"page":"3185-3187","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":84,"title":["Remarkable Increase in Central Japan in 2001-2002 of\n            <i>Neisseria gonorrhoeae<\/i>\n            Isolates with Decreased Susceptibility to Penicillin, Tetracycline, Oral Cephalosporins, and Fluoroquinolones"],"prefix":"10.1128","volume":"48","author":[{"given":"Masayasu","family":"Ito","sequence":"first","affiliation":[{"name":"Department of Urology, Gifu University School of Medicine, Gifu 500-8705"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Urology, Gifu University School of Medicine, Gifu 500-8705"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeaki","family":"Yokoi","sequence":"additional","affiliation":[{"name":"Department of Urology, Gifu University School of Medicine, Gifu 500-8705"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-ichi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Urology, Gifu University School of Medicine, Gifu 500-8705"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshito","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Urology, Gifu University School of Medicine, Gifu 500-8705"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Department of Urology, Gifu University School of Medicine, Gifu 500-8705"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-ichi","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Urology, Toyota Memorial Hospital, Toyota 471-8513, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Deguchi","sequence":"additional","affiliation":[{"name":"Department of Urology, Gifu University School of Medicine, Gifu 500-8705"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s101560170034"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.13.4.618"},{"key":"e_1_3_2_4_2","first-page":"1","volume":"51","year":"2002","unstructured":"Centers for Disease Control and Prevention. 2002. Guidelines for treatment of sexually transmitted diseases 2002. Morb. Mortal. Wkly. Rep.51(RR-06):1-80.","journal-title":"Morb. Mortal. Wkly. Rep."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.4.1020"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/00007435-199705000-00002","volume":"24","year":"1997","unstructured":"Deguchi, T., L. Saito, M. Tanaka, K. Sato, K. Deguchi, M. Yasuda, M. Nakano, Y. Nishino, E. Kanematsu, S. Ozeki, and Y. Kawada. 1997. Fluoroquinolone treatment failure in gonorrhea. Emergence of a Neisseria gonorrhoeae strain with enhanced resistance to fluoroquinolones. Sex. Transm. Dis.24:247-250.","journal-title":"Sex. Transm. Dis."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02490179"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1989.tb00101.x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.11.2799"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1099\/13500872-141-3-611"},{"key":"e_1_3_2_11_2","first-page":"7","volume":"10","year":"1999","unstructured":"Japanese Society for Sexually Transmitted Diseases. 1999. Guidelines for the diagnosis and treatment of sexually transmitted diseases. Jpn. J. Sex. Transm. Dis.10:7-38.","journal-title":"Jpn. J. Sex. Transm. Dis."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.30.5.664"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.12.3603-3606.2001"},{"key":"e_1_3_2_14_2","unstructured":"National Committee for Clinical Laboratory Standards. 2003. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard 6th ed. (M7-A6). National Committee for Clinical Laboratory Standards Wayne Pa."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8153625"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.3.1101-1106.2003"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.2.521-525.2000"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.48.8.3185-3187.2004","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.48.8.3185-3187.2004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T18:33:49Z","timestamp":1645468429000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.48.8.3185-3187.2004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2004,8]]}},"alternative-id":["10.1128\/AAC.48.8.3185-3187.2004"],"URL":"https:\/\/doi.org\/10.1128\/aac.48.8.3185-3187.2004","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,8]]},"assertion":[{"value":"2003-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-04-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}