{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:03:39Z","timestamp":1791237819301,"version":"4.1.0"},"reference-count":14,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            High-level resistance to ertapenem was produced by \u03b2-lactamases of groups 1, 2f, and 3 in a strain of\n            <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n            deficient in Omp35 and Omp36. From a wild-type strain producing ACT-1 \u03b2-lactamase, ertapenem-resistant mutants for which the ertapenem MICs were up to 128 \u03bcg\/ml and expression of outer membrane proteins was diminished could be selected.\n          <\/jats:p>","DOI":"10.1128\/aac.48.8.3203-3206.2004","type":"journal-article","created":{"date-parts":[[2004,7,23]],"date-time":"2004-07-23T18:45:20Z","timestamp":1090608320000},"page":"3203-3206","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":173,"title":["Role of \u03b2-Lactamases and Porins in Resistance to Ertapenem and Other \u03b2-Lactams in\n            <i>Klebsiella pneumoniae<\/i>"],"prefix":"10.1128","volume":"48","author":[{"given":"George A.","family":"Jacoby","sequence":"first","affiliation":[{"name":"Lahey Clinic, Burlington, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra M.","family":"Mills","sequence":"additional","affiliation":[{"name":"Lahey Clinic, Burlington, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Chow","sequence":"additional","affiliation":[{"name":"Lahey Clinic, Burlington, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.2.533-537.2004"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/10766290260469543"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.3.563"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.6.1211"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.9.2726-2732.1999"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.6.1915-1918.2001"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.8.1830"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.4.908-911.1996"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.6.1860-1867.2001"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.7.1669"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.12.3984-3986.2002"},{"key":"e_1_3_2_13_2","unstructured":"NCCLS. 2003. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically 6th ed. Approved standard M7-A6. NCCLS Wayne Pa."},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0732-8893(01)00335-2","volume":"42","year":"2002","unstructured":"Ribera, A., A. Jurado, J. Ruiz, F. Marco, O. Del Valle, J. Mensa, J. Chaves, G. Hern\u00e1ndez, M. T. Jim\u00e9nez de Anta, and J. Vila. 2002. In vitro activity of clinafloxacin in comparison with other quinolones against Stenotrophomonas maltophilia clinical isolates in the presence and absence of reserpine. Diagn. Microbiol. Infect. Dis.42:123-128.","journal-title":"Diagn. Microbiol. Infect. 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