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Cloning and expression in<jats:italic>Escherichia coli<\/jats:italic>identified the carbapenem-hydrolyzing \u03b2-lactamase OXA-58, which is weakly related (less than 50% amino acid identity) to other oxacillinases. It hydrolyzed penicillins, oxacillin, and imipenem but not expanded-spectrum cephalosporins. The<jats:italic>bla<\/jats:italic><jats:sub>OXA-58<\/jats:sub>gene was located on a ca. 30-kb non-self-transferable plasmid. After electrotransformation in the<jats:italic>A. baumannii<\/jats:italic>CIP7010<jats:sup>T<\/jats:sup>reference strain, it conferred reduced susceptibility to carbapenems. The<jats:italic>bla<\/jats:italic><jats:sub>OXA-58<\/jats:sub>gene was bracketed by two novel IS<jats:italic>Aba3-<\/jats:italic>like insertion elements. 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