{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:51:57Z","timestamp":1773294717770,"version":"3.50.1"},"reference-count":16,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Core tonsillar cultures were obtained from 40 children with recurrent tonsillitis treated with either penicillin or cefdinir. Group A beta-hemolytic streptococci were isolated from 11 penicillin- and 3 cefdinir-treated (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001) patients. \u03b2-Lactamase producers were recovered from 17 penicillin- and 3 cefdinir-treated (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.01) patients. Inhibiting alpha-hemolytic streptococci were isolated less often from penicillin-treated patients than from cefdinir-treated patients.\n          <\/jats:p>","DOI":"10.1128\/aac.49.11.4787-4788.2005","type":"journal-article","created":{"date-parts":[[2005,10,26]],"date-time":"2005-10-26T16:37:59Z","timestamp":1130344679000},"page":"4787-4788","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Efficacy of Penicillin versus Cefdinir in Eradication of Group A Streptococci and Tonsillar Flora"],"prefix":"10.1128","volume":"49","author":[{"given":"Itzhak","family":"Brook","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Georgetown University School of Medicine, Washington, D.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perry A.","family":"Foote","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University of Florida, Alachua General Hospital, Gainesville, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/clinids\/6.5.601","volume":"6","year":"1984","unstructured":"Brook, I. 1984. The role of beta-lactamase-producing bacteria in the persistence of streptococcal tonsillar infection. Rev. Infect. Dis.6:601-607.","journal-title":"Rev. Infect. Dis."},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"556","DOI":"10.3109\/00016488409107597","volume":"98","year":"1984","unstructured":"Brook, I., and P. Yocum. 1984. Quantitative measurement of beta-lactamase in tonsils of children with recurrent tonsillitis. Acta Oto-Laryngol.98:556-559.","journal-title":"Acta Oto-Laryngol."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.7.1452"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1001\/archotol.1995.01890120061012","volume":"121","year":"1995","unstructured":"Brook, I., and A. E. Gober. 1995. Role of bacterial interference and beta-lactamase-producing bacteria in the failure of penicillin to eradicate group A streptococcal pharyngotonsillitis. Arch. Otolaryngol. 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