{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:25:36Z","timestamp":1791296736395,"version":"4.1.0"},"reference-count":43,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            While\n            <jats:italic>Candida albicans<\/jats:italic>\n            remains the most common\n            <jats:italic>Candida<\/jats:italic>\n            isolate,\n            <jats:italic>Candida glabrata<\/jats:italic>\n            accounts for approximately 15 to 20% of all\n            <jats:italic>Candida<\/jats:italic>\n            infections in the United States. In this study we used immunosuppressed mice infected with\n            <jats:italic>C. glabrata<\/jats:italic>\n            to investigate the efficacy of liposomal amphotericin B alone or in combination with the echinocandin caspofungin or micafungin. For monotherapy, mice were given six daily doses of liposomal amphotericin B (3 to 20 mg\/kg of body weight), caspofungin (1 to 5 mg\/kg), or micafungin (2.5 to 10 mg\/kg). With concomitant therapy, mice received liposomal amphotericin B (7.5 mg\/kg) in addition to caspofungin (2.5 mg\/kg) or micafungin (2.5 mg\/kg) for 6 days. For sequential therapy, liposomal amphotericin B was administered on days 1 to 3 and caspofungin or micafungin was given on days 4 to 6; conversely, caspofungin or micafungin was administered on days 1 to 3 and liposomal amphotericin B was given on days 4 to 6. Efficacy was based on the number of CFU per gram of kidney 21 days postchallenge. Monotherapy with liposomal amphotericin B (7.5 to 20 mg\/kg) was significantly more effective than no drug treatment (control group) (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.05) and demonstrated a dose-dependent response, with 20 mg\/kg lowering the CFU\/g from 6.3 to 4.2 (significantly different from the value for the control group [\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001]). Monotherapy with all echinocandin doses lowered the CFU\/g from 6.0 to 6.4 to 2.7 to 3.3 (significantly different from the value for the control group [\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001]) with no dose-dependent response. Complete clearance of infection could be achieved only when liposomal amphotericin B was given either concomitantly with caspofungin or micafungin or if liposomal amphotericin B was given sequentially with caspofungin. In conclusion, the combination of liposomal amphotericin B with an echinocandin markedly improved the therapeutic outcome in murine\n            <jats:italic>C. glabrata<\/jats:italic>\n            systemic infection.\n          <\/jats:p>","DOI":"10.1128\/aac.49.12.4895-4902.2005","type":"journal-article","created":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T21:57:58Z","timestamp":1132696678000},"page":"4895-4902","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":70,"title":["Treatment of\n            <i>Candida glabrata<\/i>\n            Infection in Immunosuppressed Mice by Using a Combination of Liposomal Amphotericin B with Caspofungin or Micafungin"],"prefix":"10.1128","volume":"49","author":[{"given":"Jon A.","family":"Olson","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, California State Polytechnic University, Pomona, California 91768"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill P.","family":"Adler-Moore","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, California State Polytechnic University, Pomona, California 91768"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. J.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, California State Polytechnic University, Pomona, California 91768"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard T.","family":"Proffitt","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, California State Polytechnic University, Pomona, California 91768"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/513663"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.11.2333"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh460"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/23.5.964"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.9.3312-3316.2004"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.5.1773-1777.2004"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-002-0730-4"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.8.2420-2426.2002"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-003-0973-8"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"585","DOI":"10.2165\/00003495-199855040-00008","volume":"55","year":"1998","unstructured":"Coukell, A. 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