{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:09:14Z","timestamp":1791234554096,"version":"4.1.0"},"reference-count":28,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We report in this study the in vivo efficacy of nine 2-substituted quinolines on the\n            <jats:italic>Leishmania amazonensis<\/jats:italic>\n            cutaneous infection murine model and on the\n            <jats:italic>Leishmania infantum<\/jats:italic>\n            and\n            <jats:italic>Leishmania donovani<\/jats:italic>\n            visceral infection murine models. In the case of the\n            <jats:italic>L. amazonensis<\/jats:italic>\n            model, quinolines were administered orally at 25 mg\/kg twice daily for 15 days. Quinolines 1, 2, 3, and 7 reduced by 80 to 90% the parasite burdens in the lesion, whereas\n            <jats:italic>N<\/jats:italic>\n            -methylglucamine antimoniate (Glucantime), administered by subcutaneous injections at 100 mg [28 mg Sb(V)] per kg of body weight daily, reduced the parasite burdens by 98%. In visceral leishmaniasis due to\n            <jats:italic>L.\u2009infantum<\/jats:italic>\n            , mice treated orally at 25 mg\/kg daily for 10 days with quinolines 1, 4, 5, and 6 showed a significant reduction of parasite burdens in the liver and spleen. These quinolines were significantly more effective than meglumine antimoniate to reduce the parasite burden in both the liver and spleen. Also, the oral in vivo activity of three quinolines (quinolines 4, 5, and 2-\n            <jats:italic>n<\/jats:italic>\n            -propylquinoline) were determined against\n            <jats:italic>L. donovani<\/jats:italic>\n            (LV 9) at 12.5 and 25 mg\/kg for 10 days. Their activity was compared with that of miltefosine at 7.5 mg\/kg. Miltefosine, 2-\n            <jats:italic>n<\/jats:italic>\n            -propylquinoline, and quinoline 5 at 12.5 mg\/kg significantly reduced the parasite burdens in the liver by 72, 66, and 61%, respectively. From the present study, quinoline 5 is the most promising compound against both cutaneous and visceral leishmaniasis. The double antileishmanial and antiviral activities of these compounds suggest that this series could be a potential treatment for coinfection of\n            <jats:italic>Leishmania<\/jats:italic>\n            -human immunodeficiency virus.\n          <\/jats:p>","DOI":"10.1128\/aac.49.12.4950-4956.2005","type":"journal-article","created":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T21:57:58Z","timestamp":1132696678000},"page":"4950-4956","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":77,"title":["Efficacy of Orally Administered 2-Substituted Quinolines in Experimental Murine Cutaneous and Visceral Leishmaniases"],"prefix":"10.1128","volume":"49","author":[{"given":"Hector","family":"Nakayama","sequence":"first","affiliation":[{"name":"Department of Tropical Medicine, Casilla de Correo 2511, Instituto de Investigaciones en Ciencias de la Salud Asuncio\u0301n, Universidad Nacional de Asuncion, Paraguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe M.","family":"Loiseau","sequence":"additional","affiliation":[{"name":"Laboratoire de Pharmacognosie et Groupe Chimiothe\u0301rapie Antiparasitaire UMR 8076 CNRS, Faculte\u0301 de Pharmacie, Universite\u0301 Paris-Sud, rue J.B. Cle\u0301ment, 92296 Cha\u0304tenay-Malabry ce\u0301dex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Bories","sequence":"additional","affiliation":[{"name":"Laboratoire de Pharmacognosie et Groupe Chimiothe\u0301rapie Antiparasitaire UMR 8076 CNRS, Faculte\u0301 de Pharmacie, Universite\u0301 Paris-Sud, rue J.B. Cle\u0301ment, 92296 Cha\u0304tenay-Malabry ce\u0301dex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Torres de Ortiz","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine, Casilla de Correo 2511, Instituto de Investigaciones en Ciencias de la Salud Asuncio\u0301n, Universidad Nacional de Asuncion, Paraguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Schinini","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine, Casilla de Correo 2511, Instituto de Investigaciones en Ciencias de la Salud Asuncio\u0301n, Universidad Nacional de Asuncion, Paraguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Serna","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine, Casilla de Correo 2511, Instituto de Investigaciones en Ciencias de la Salud Asuncio\u0301n, Universidad Nacional de Asuncion, Paraguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonieta","family":"Rojas de Arias","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine, Casilla de Correo 2511, Instituto de Investigaciones en Ciencias de la Salud Asuncio\u0301n, Universidad Nacional de Asuncion, Paraguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Fakhfakh","sequence":"additional","affiliation":[{"name":"Laboratoire de Pharmacognosie et Groupe Chimiothe\u0301rapie Antiparasitaire UMR 8076 CNRS, Faculte\u0301 de Pharmacie, Universite\u0301 Paris-Sud, rue J.B. 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