{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T03:37:30Z","timestamp":1789529850078,"version":"build-2803163510"},"reference-count":38,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The susceptibilities of nonduplicate isolates to six antifungal agents were determined for 391 blood isolates of seven\n                    <jats:italic>Candida<\/jats:italic>\n                    species, 70 clinical isolates (from blood or cerebrospinal fluid) of\n                    <jats:italic>Cryptococcus neoformans<\/jats:italic>\n                    , and 96 clinical isolates of four\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    species, which were collected in seven different hospitals in Taiwan (as part of the 2003 program of the study group Surveillance of Multicenter Antimicrobial Resistance in Taiwan). All isolates of\n                    <jats:italic>Candida<\/jats:italic>\n                    species other than\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    and\n                    <jats:italic>C. krusei<\/jats:italic>\n                    were susceptible to fluconazole. Among the 59\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    isolates, 16 (27%) were not susceptible to fluconazole, and all were dose-dependently susceptible or resistant to itraconazole. For three (5.1%)\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    isolates, voriconazole MICs were 2 to 4 \u03bcg\/ml, and for all other\n                    <jats:italic>Candida<\/jats:italic>\n                    species isolates, voriconazole MICs were \u22640.5 \u03bcg\/ml. The proportions of isolates for which amphotericin B MICs were \u22652 \u03bcg\/ml were 100% (3 isolates) for\n                    <jats:italic>C. krusei<\/jats:italic>\n                    , 11% (23 of 207 isolates) for\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    , 3.0% (2 of 67 isolates) for\n                    <jats:italic>Candida tropicalis<\/jats:italic>\n                    , 20% (12 of 59 isolates) for\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    , and 0% for both\n                    <jats:italic>Candida parapsilosis<\/jats:italic>\n                    and\n                    <jats:italic>Candida lusitaniae<\/jats:italic>\n                    . For three (4%)\n                    <jats:italic>Cryptococcus neoformans<\/jats:italic>\n                    isolates, fluconazole MICs were \u226516 \u03bcg\/ml, and two (3%) isolates were not inhibited by 1 \u03bcg of amphotericin B\/ml. For four (4.2%) of the\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    isolates, itraconazole MICs were 8 \u03bcg\/ml.\n                    <jats:italic>Aspergillus flavus<\/jats:italic>\n                    was less susceptible to amphotericin B, with the MICs at which 50% (1 \u03bcg\/ml) and 90% (2 \u03bcg\/ml)\n                    <jats:italic>nsrsid417869\\delrsid7301351<\/jats:italic>\n                    of isolates were inhibited being twofold greater than those for\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    and\n                    <jats:italic>Aspergillus niger<\/jats:italic>\n                    . All\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    isolates were inhibited by \u22641 \u03bcg of voriconazole\/ml, including isolates with increased resistance to amphotericin B and itraconazole. This study revealed the emergence in Taiwan of decreased susceptibilities of\n                    <jats:italic>Candida<\/jats:italic>\n                    species to amphotericin B and of\n                    <jats:italic>C. neoformans<\/jats:italic>\n                    to fluconazole and amphotericin B. Voriconazole was the most potent agent against the fungal isolates tested, including fluconazole- and amphotericin B-nonsusceptible strains.\n                  <\/jats:p>","DOI":"10.1128\/aac.49.2.512-517.2005","type":"journal-article","created":{"date-parts":[[2005,1,26]],"date-time":"2005-01-26T17:04:40Z","timestamp":1106759080000},"page":"512-517","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":81,"title":["Antifungal Susceptibilities of Clinical Isolates of\n                    <i>Candida<\/i>\n                    Species,\n                    <i>Cryptococcus neoformans<\/i>\n                    , and\n                    <i>Aspergillus<\/i>\n                    Species from Taiwan: Surveillance of Multicenter Antimicrobial Resistance in Taiwan Program Data from 2003"],"prefix":"10.1128","volume":"49","author":[{"given":"Po-Ren","family":"Hsueh","sequence":"first","affiliation":[{"name":"Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeu-Jun","family":"Lau","sequence":"additional","affiliation":[{"name":"Taichung Veterans General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin-Ching","family":"Chuang","sequence":"additional","affiliation":[{"name":"Chi-Mei Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen-Hsien","family":"Wan","sequence":"additional","affiliation":[{"name":"China Medical College Hospital, Taichung"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Kuei","family":"Huang","sequence":"additional","affiliation":[{"name":"Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jainn-Ming","family":"Shyr","sequence":"additional","affiliation":[{"name":"Taichung Veterans General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Jou","family":"Yan","sequence":"additional","affiliation":[{"name":"National Cheng-Kung University Hospital, Tainan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwok-Woon","family":"Yu","sequence":"additional","affiliation":[{"name":"Taipei Veterans General Hospital, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiunn-Jong","family":"Wu","sequence":"additional","affiliation":[{"name":"National Cheng-Kung University Hospital, Tainan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Chien","family":"Ko","sequence":"additional","affiliation":[{"name":"National Cheng-Kung University Hospital, Tainan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chueh","family":"Yang","sequence":"additional","affiliation":[{"name":"Chi-Mei Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Ching","family":"Liu","sequence":"additional","affiliation":[{"name":"China Medical College Hospital, Taichung"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee-Jene","family":"Teng","sequence":"additional","affiliation":[{"name":"Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Taipei Veterans General Hospital, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwen-Tay","family":"Luh","sequence":"additional","affiliation":[{"name":"Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(98)00102-3"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.6.1544-1548.2000"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.12.3946-3951.1999"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.4.1197-1203.2004"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.3.531-537.1999"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(01)00295-4"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1378\/chest.120.1.177","volume":"120","year":"2001","unstructured":"Chen, K. 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