{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:37:34Z","timestamp":1792813054790,"version":"4.5.0"},"reference-count":9,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Several arylpiperazines capable of reversing multidrug resistance (MDR) in\n            <jats:italic>Escherichia coli<\/jats:italic>\n            overexpressing\n            <jats:italic>acrAB<\/jats:italic>\n            and\n            <jats:italic>acrEF<\/jats:italic>\n            but not in pump-deficient mutant strains were identified. 1-(1-Naphthylmethyl)-piperazine, one of the more active compounds, enhanced susceptibility to fluoroquinolones and other agents and increased the intracellular concentration of levofloxacin and ethidium bromide, suggesting efflux pump inhibition as the mechanism of MDR reversal.\n          <\/jats:p>","DOI":"10.1128\/aac.49.2.849-852.2005","type":"journal-article","created":{"date-parts":[[2005,1,26]],"date-time":"2005-01-26T22:04:40Z","timestamp":1106777080000},"page":"849-852","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":207,"title":["Selected Arylpiperazines Are Capable of Reversing Multidrug Resistance in\n            <i>Escherichia coli<\/i>\n            Overexpressing RND Efflux Pumps"],"prefix":"10.1128","volume":"49","author":[{"given":"Ju\u0308rgen A.","family":"Bohnert","sequence":"first","affiliation":[{"name":"Center for Infectious Diseases and Travel Medicine, Department of Medicine, University Hospital, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winfried V.","family":"Kern","sequence":"additional","affiliation":[{"name":"Center for Infectious Diseases and Travel Medicine, Department of Medicine, University Hospital, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.5.1467-1472.2001"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.4.814-820.2000"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200464020-00004"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.1.105-116.2001"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj20030963"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2004.00763.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm9904598"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.4.1126-1136.2001"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/S0960-894X(01)00330-4","volume":"11","year":"2001","unstructured":"Thorarensen, A., A. L. Presley-Bodnar, K. R. Marotti, T. P. Boyle, C. L. Heckaman, M. J. Bohanon, P. K. Tomich, G. E. Zurenko, M. T. Sweeney, and B. H. Yagi. 2001. 3-Arylpiperidines as potentiators of existing antibacterial agents. Bioorg. Med. Chem. Lett.11:1903-1906.","journal-title":"Bioorg. Med. Chem. 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