{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:37:02Z","timestamp":1789011422524,"version":"build-2803163510"},"reference-count":13,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            A combination of Cpl-1, a bacteriophage lytic enzyme, and penicillin, gentamicin, levofloxacin, or azithromycin was tested against\n            <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n            strains with various susceptibilities to penicillin. Activities of Cpl-1 and gentamicin were increasingly synergistic with a decreasing penicillin MIC, while Cpl-1 and penicillin showed synergy against an extremely penicillin-resistant strain.\n          <\/jats:p>","DOI":"10.1128\/aac.49.3.1225-1228.2005","type":"journal-article","created":{"date-parts":[[2005,2,23]],"date-time":"2005-02-23T22:51:53Z","timestamp":1109199113000},"page":"1225-1228","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":98,"title":["Synergistic Killing of\n            <i>Streptococcus pneumoniae<\/i>\n            with the Bacteriophage Lytic Enzyme Cpl-1 and Penicillin or Gentamicin Depends on the Level of Penicillin Resistance"],"prefix":"10.1128","volume":"49","author":[{"given":"Svetolik","family":"Djurkovic","sequence":"first","affiliation":[{"name":"Laboratory of Bacterial Pathogenesis, The Rockefeller University"},{"name":"Sloan Kettering Cancer Institute, Division of Infectious Disease, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutta M.","family":"Loeffler","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Pathogenesis, The Rockefeller University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent A.","family":"Fischetti","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Pathogenesis, The Rockefeller University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","first-page":"53","year":"1991","unstructured":"Amsterdam, D. 1991. 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