{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:41:47Z","timestamp":1791121307243,"version":"4.1.0"},"reference-count":7,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            LBM415 activity against extracellular and intracellular\n            <jats:italic>Legionella pneumophila<\/jats:italic>\n            was studied. The LBM415 MIC\n            <jats:sub>50<\/jats:sub>\n            for 20\n            <jats:italic>Legionella<\/jats:italic>\n            sp. strains was 4 \u03bcg\/ml, versus 0.06, 0.25, and \u2264 0.03 \u03bcg\/ml for azithromycin, erythromycin, and levofloxacin, respectively. LBM415 (0.5 and 16 \u03bcg\/ml) reversibly prevented intracellular growth of two\n            <jats:italic>L. pneumophila<\/jats:italic>\n            strains and was less active than erythromycin.\n          <\/jats:p>","DOI":"10.1128\/aac.49.6.2533-2535.2005","type":"journal-article","created":{"date-parts":[[2005,5,25]],"date-time":"2005-05-25T23:07:56Z","timestamp":1117062476000},"page":"2533-2535","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":9,"title":["In Vitro and Intracellular Activities of LBM415 (NVP PDF-713) against\n            <i>Legionella pneumophila<\/i>"],"prefix":"10.1128","volume":"49","author":[{"given":"Paul H.","family":"Edelstein","sequence":"first","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine"},{"name":"Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4283"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baofeng","family":"Hu","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha A. C.","family":"Edelstein","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.33.12.2132"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.35.1.180"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.31.12.3329-3330.1993"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/jac\/37.1.117","volume":"37","year":"1996","unstructured":"Edelstein, P. H., M. A. C. Edelstein, K. H. Lehr, and J. Ren. 1996. In-vitro activity of levofloxacin against clinical isolates of Legionella spp., its pharmacokinetics in guinea pigs, and use in experimental Legionella pneumophila pneumonia. J. Antimicrob. Chemother.37:117-126.","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.2.533-540.2003"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109874"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh184"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.49.6.2533-2535.2005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.49.6.2533-2535.2005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:17:47Z","timestamp":1645485467000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.49.6.2533-2535.2005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":7,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["10.1128\/AAC.49.6.2533-2535.2005"],"URL":"https:\/\/doi.org\/10.1128\/aac.49.6.2533-2535.2005","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6]]},"assertion":[{"value":"2004-09-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-02-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}