{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T17:04:09Z","timestamp":1694624649178},"reference-count":15,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            This study analyzes the in vitro activities of levofloxacin and other commonly used antimicrobials against middle ear fluid, nasopharyngeal, and oropharyngeal pathogens obtained from children with otitis media at risk of having a resistant pathogen. Levofloxacin proved to be very active against these pathogens and had intermediate activity against\n            <jats:italic>Streptococcus pyogenes<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.49.7.3056-3058.2005","type":"journal-article","created":{"date-parts":[[2005,6,25]],"date-time":"2005-06-25T02:22:50Z","timestamp":1119666170000},"page":"3056-3058","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["In Vitro Activities of Levofloxacin and Comparable Agents against Middle Ear Fluid, Nasopharyngeal, and Oropharyngeal Pathogens Obtained from Costa Rican Children with Recurrent Otitis Media or Failing Other Antibiotic Therapy"],"prefix":"10.1128","volume":"49","author":[{"given":"Carolina","family":"Soley","sequence":"first","affiliation":[{"name":"Instituto de Atencio\u0301n Pedia\u0301trica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano","family":"Arguedas","sequence":"additional","affiliation":[{"name":"Instituto de Atencio\u0301n Pedia\u0301trica"},{"name":"Universidad de Ciencias Me\u0301dicas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Porras","sequence":"additional","affiliation":[{"name":"Instituto de Atencio\u0301n Pedia\u0301trica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Guevara","sequence":"additional","affiliation":[{"name":"Instituto de Atencio\u0301n Pedia\u0301trica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Loaiza","sequence":"additional","affiliation":[{"name":"Instituto de Atencio\u0301n Pedia\u0301trica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Pe\u0301rez","sequence":"additional","affiliation":[{"name":"Instituto de Atencio\u0301n Pedia\u0301trica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Rinco\u0301n","sequence":"additional","affiliation":[{"name":"Instituto de Atencio\u0301n Pedia\u0301trica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malka","family":"Schultz","sequence":"additional","affiliation":[{"name":"Instituto de Atencio\u0301n Pedia\u0301trica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Arguedas","sequence":"additional","affiliation":[{"name":"Instituto de Atencio\u0301n Pedia\u0301trica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Brilla","sequence":"additional","affiliation":[{"name":"Laboratorio Centro de Investigaciones Me\u0301dicas, San Jose\u0301, Costa Rica"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.5.1451"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1097\/01.inf.0000101189.81501.e9","volume":"22","year":"2003","unstructured":"Arguedas, A., R. Dagan, C. Soley, C. Loaiza, K. Knudsen, N. Porat, A. P\u00e9rez, E. Brilla, and M. Herrera. 2003. Microbiology of otitis media in Costa Rican children, 1999 through 2001. Pediatr. Infect. Dis. J.22:1063-1068.","journal-title":"Pediatr. Infect. Dis. J."},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1097\/00006454-199808000-00004","volume":"17","year":"1998","unstructured":"Arguedas, A., C. Loaiza, A. P\u00e9rez, F. Vargas, M. Herrera, G. Rodr\u00edguez, A. Guti\u00e9rrez, and E. Mohs. 1998. Microbiology of acute otitis media in Costa Rican children. Pediatr. Infect. Dis. J.17:680-689.","journal-title":"Pediatr. Infect. Dis. J."},{"key":"e_1_3_2_5_2","unstructured":"Arguedas A. C. Soley E. Brilla W. Porras S. Guevara C. Loaiza A. P\u00e9rez H. Sierra G. German G. Rinc\u00f3n M. Schultz and J. Arguedas. 2004. In-vitro activity of levofloxacin against middle ear fluid nasopharyngeal and oropharyngeal pathogens obtained from Costa Rican children with otitis media abstr. G-2086. Abstr. 44th Intersci. Conf. Antimicrob. Agents Chemother. American Society for Microbiology Washington D.C."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000095193.42502.d1"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/jac\/dkf152","volume":"50","year":"2002","unstructured":"Boswell, F. J., J. Andrews, G. Jevons, and R. Wise. 2002. Comparison of the in vitro activities of several new fluoroquinolones against respiratory pathogens and their abilities to select fluoroquinolone resistance. J. Antimicrob. Chemother.50:495-502.","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/01.inf.0000126272.08795.7a","volume":"23","year":"2004","unstructured":"Dagan, R., A. 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