{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:02:12Z","timestamp":1791414132718,"version":"4.3.3"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2006,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n The antibacterial activity of XRP2868, a new oral streptogramin composed of a combination of RPR132552 (streptogramin A) and RPR202868 (streptogramin B), was evaluated against a collection of clinical gram-positive isolates with characterized phenotypes and genotypes of streptogramin resistance. The effects of genes for resistance to streptogramin A or B on the activity of XRP2868 and its components were also tested by cloning these genes individually or in various combinations in gram-positive recipient strains susceptible to quinupristin-dalfopristin. The species tested included\n Staphylococcus aureus<\/jats:italic>\n , coagulase-negative staphylococci,\n Enterococcus faecalis<\/jats:italic>\n ,\n Enterococcus faecium<\/jats:italic>\n ,\n Streptococcus pneumoniae<\/jats:italic>\n , and other species of streptococci. XRP2868 was generally fourfold more potent than quinupristin-dalfopristin against\n S. aureus<\/jats:italic>\n ,\n E. faecium<\/jats:italic>\n , and streptococci and had activity against\n E. faecalis<\/jats:italic>\n (MICs = 0.25 to 1 \u03bcg\/ml). XRP2868 appeared to be affected by the same mechanisms of resistance as those to quinupristin-dalfopristin. Nevertheless, the strong activity of factor A of the oral streptogramin enabled the combination to be very potent against streptogramin-susceptible staphylococci, streptococci, and\n E. faecium<\/jats:italic>\n (MICs = 0.03 to 0.25 \u03bcg\/ml) and to retain low MICs against the strains harboring a mechanism of resistance to factor A or factor B of the streptogramin. However, the combination of mechanisms of resistance to factors A and B caused an increase in the MICs of XRP2868, which reached 1 to 4 \u03bcg\/ml. As with the other streptogramins, there was a reduction in the bactericidal effect of XRPR2868 when the staphylococcal strains acquired a constitutively expressed\n erm<\/jats:italic>\n gene.\n <\/jats:p>","DOI":"10.1128\/aac.50.1.237-242.2006","type":"journal-article","created":{"date-parts":[[2005,12,23]],"date-time":"2005-12-23T10:07:51Z","timestamp":1135332471000},"page":"237-242","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Activity of a New Oral Streptogramin, XRP2868, against Gram-Positive Cocci Harboring Various Mechanisms of Resistance to Streptogramins"],"prefix":"10.1128","volume":"50","author":[{"given":"Michel","family":"Dupuis","sequence":"first","affiliation":[{"name":"Service de Microbiologie and EA 2128 Relations Ho\u0302te et Microorganismes des E\u0301pithe\u0301liums, Ho\u0302pital Co\u0302te de Nacre, Universite\u0301 de Caen, 14033 Caen cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Leclercq","sequence":"additional","affiliation":[{"name":"Service de Microbiologie and EA 2128 Relations Ho\u0302te et Microorganismes des E\u0301pithe\u0301liums, Ho\u0302pital Co\u0302te de Nacre, Universite\u0301 de Caen, 14033 Caen cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00011229"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.9.1899"},{"key":"e_1_3_2_4_2","first-page":"155","volume":"4","year":"1998","unstructured":"Barriere, J. C., N. Berthaud, D. Beyer, S. Dutka-Malen, J. M. Paris, and J. F. Desnottes. 1998. Recent developments in streptogramin research. Curr. Pharm. Des.4:155-180.","journal-title":"Curr. Pharm. Des."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.11.2720"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568005014606152"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.1.125-131.2002"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2004.06.016"},{"key":"e_1_3_2_9_2","unstructured":"Comit\u00e9 de l'Antibiogramme de la Soci\u00e9t\u00e9 Fran\u00e7aise de Microbiologie. 2004. Communiqu\u00e9 2004. Soci\u00e9t\u00e9 Fran\u00e7aise de Microbiologie. http:\/\/www.sfm.asso.fr\/\n. Last release January 2004."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.7.2307-2309.2003"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.7.3034-3039.2005"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.10.2880-2882.2000"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.1.408-413.2005"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/383146"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/324626"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.7.2200-2207.2002"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh493"},{"key":"e_1_3_2_18_2","unstructured":"National Committee for Clinical Laboratory Standards. 1992. Methods for determining bactericidal activity of antimicrobial agents. Proposed guideline M26-T. National Committee for Clinical Laboratory Standards Villanova Pa."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.10.3270-3274.2003"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.71.5.2796-2799.2005"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1990.tb00696.x"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/44.suppl_1.37"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.6.1845-1850.2002"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.5.1168-1173.2000"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.50.1.237-242.2006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.50.1.237-242.2006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T19:05:28Z","timestamp":1645470328000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.50.1.237-242.2006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1128\/AAC.50.1.237-242.2006"],"URL":"https:\/\/doi.org\/10.1128\/aac.50.1.237-242.2006","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"2005-09-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-10-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}