{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T04:23:30Z","timestamp":1789446210908,"version":"build-2803163510"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Paecilomyces lilacinus<\/jats:italic>\n            is a fungal pathogen which is generally resistant to amphotericin B and certain other antifungals and is an uncommon cause of devastating fungal keratitis. In the present studies, we evaluated topical voriconazole as therapy for\n            <jats:italic>P. lilacinus<\/jats:italic>\n            keratitis in rabbits. Thirty eyes of 15 rabbits were studied. In five animals, the uninfected left eye was treated twice daily with voriconazole (drug control, uninfected eye). In these same animals, the right eye was infected with\n            <jats:italic>P. lilacinus<\/jats:italic>\n            but not treated with voriconazole (infection control eye). By day 5, the infection controls had lesions of &gt;2.4 mm in diameter, with conjunctivitis and severe hypopyon, and were sacrificed. In the other 10 rabbits (voriconazole treatment), the right eyes were infected with\n            <jats:italic>P. lilacinus<\/jats:italic>\n            and treated with voriconazole beginning on day 3 after infection. Voriconazole therapy caused lesions to decrease during 8 days of therapy, after which rabbits were sacrificed (11 days postinfection). Hyphal masses were present in the control infected eyes and absent in treated infected eyes. Voriconazole was detected in all tissues of treated eyes. Topical voriconazole is effective treatment for\n            <jats:italic>P. lilacinus<\/jats:italic>\n            experimental keratitis, and it penetrates more deeply than the corneal tissue.\n          <\/jats:p>","DOI":"10.1128\/aac.50.1.262-268.2006","type":"journal-article","created":{"date-parts":[[2005,12,23]],"date-time":"2005-12-23T10:07:51Z","timestamp":1135332471000},"page":"262-268","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":64,"title":["Topical Voriconazole as a Novel Treatment for Fungal Keratitis"],"prefix":"10.1128","volume":"50","author":[{"given":"William","family":"Sponsel","sequence":"first","affiliation":[{"name":"The University of Texas Health Science Center at San Antonio, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Chen","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at San Antonio, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demi","family":"Dang","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at San Antonio, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianmarco","family":"Paris","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at San Antonio, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Graybill","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at San Antonio, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura K.","family":"Najvar","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at San Antonio, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute, The National University of Singapore, Republic of Singapore;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwok-Wai","family":"Lam","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute, The National University of Singapore, Republic of Singapore;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randolph","family":"Glickman","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at San Antonio, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Scribbick","sequence":"additional","affiliation":[{"name":"Brooke Army Medical Center, Fort Sam Houston, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/00362177985380541"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/324620"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1975.01010020850004"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(98)00004-1"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.4.1359-1363.2005"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/00362178585380421"},{"key":"e_1_3_2_8_2","first-page":"705","volume":"146","year":"1966","unstructured":"Halde, C., and M. Okumoto. 1966. Ocular mycoses: a study of 82 cases. Proceedings of the XX International Congress of Ophthalmology, Munich. Excerpta Med. Int. Congr. Ser.146:705-715.","journal-title":"Int. Congr. Ser."},{"key":"e_1_3_2_9_2","first-page":"25","volume":"16","year":"1973","unstructured":"Henig, F. E., N. Lehrer, A. Gabbay, and O. Kurz. 1973. Paecilomycosis of the lacrimal sac. Mykosen16:25-28.","journal-title":"Mykosen"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020191"},{"key":"e_1_3_2_11_2","first-page":"183","volume":"101","year":"2003","unstructured":"Hua, G., M. Pennesi, K. Shah, X. Qiao, S. M. Hariprasad, W. F. Mieler, S. M. Wu, and E. R. Holz. 2003. Safety of intravitreal voriconazole: electroretinographic and histopathologic studies. Trans. Am. Ophthalmol. Soc.101:183-189.","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/367933"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/430062"},{"key":"e_1_3_2_14_2","first-page":"54","volume":"9","year":"1978","unstructured":"Miller, G. R., G. Rebell, R. C. Magoon, S. M. Kulvin, and R. K. Forster. 1978. Intravitreal antimycotic therapy and cure of mycotic endophthalmitis caused by Paecilomyces lilacinus contaminated pseudophakos. Ophthalmic. Surg.9:54-63.","journal-title":"Ophthalmic. Surg."},{"key":"e_1_3_2_15_2","unstructured":"National Committee for Clinical Laboratory Standards. 1998. Reference method for broth dilution antifungal susceptibility testing of conidium-forming filamentous fungi. Approved standard M38-P. National Committee for Clinical Laboratory Standards Wayne Pa."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(77)90206-9"},{"key":"e_1_3_2_17_2","first-page":"45","volume":"36","year":"1996","unstructured":"O'Day, D. M. 1996. New antifungal drugs in ophthalmology. Int. Ophthalmol. Clin.36:45-51.","journal-title":"Int. Ophthalmol. Clin."},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1086\/374557"},{"key":"e_1_3_2_19_2","first-page":"1","volume":"6","year":"1974","unstructured":"Samson, R. A. 1974. Paecilomyces and some allied hyphomycetes, p. 1-119. InStudies in mycology,vol. 6. Centraalbureau voor Schimmelcultures, Baarn, The Netherlands.","journal-title":"Studies in mycology"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(96)00408-2"},{"key":"e_1_3_2_21_2","first-page":"290","year":"1998","unstructured":"Sutton, D., A. W. Fothergill, and M. G. Rinaldi. 1998. Guide to clinically significant fungi, p. 290-291. 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