{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:30:42Z","timestamp":1792099842339,"version":"4.4.0"},"reference-count":16,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Standardized susceptibility testing fails to predict in vivo resistance of device-related infections to antimicrobials. We assessed agents and combinations of antimicrobials against clinical isolates of\n            <jats:italic>Staphylococcus epidermidis<\/jats:italic>\n            and\n            <jats:italic>S. aureus<\/jats:italic>\n            (methicillin-resistant\n            <jats:italic>S. aureus<\/jats:italic>\n            and methicillin-sensitive\n            <jats:italic>S. aureus<\/jats:italic>\n            ) retrieved from device-associated infections. Isolates were grown planktonically and as biofilms. Biofilm cultures of the organisms were found to be much more resistant to inhibitory and bactericidal effects of single and combination antibiotics than planktonic cultures (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001). Rifampin was the most common constituent of antibiotic combinations active against staphylococcal biofilms. Other frequently effective antimicrobials were vancomycin and fusidic acid. Susceptibility testing involving biofilm-associated bacteria suggests new options for combination antibiotic therapy.\n          <\/jats:p>","DOI":"10.1128\/aac.50.1.55-61.2006","type":"journal-article","created":{"date-parts":[[2005,12,23]],"date-time":"2005-12-23T10:07:51Z","timestamp":1135332471000},"page":"55-61","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":274,"title":["Multiple Combination Bactericidal Testing of Staphylococcal Biofilms from Implant-Associated Infections"],"prefix":"10.1128","volume":"50","author":[{"given":"Raphael","family":"Saginur","sequence":"first","affiliation":[{"name":"The Ottawa Hospital"},{"name":"University of Ottawa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"StDenis","sequence":"additional","affiliation":[{"name":"University of Ottawa"},{"name":"Children's Hospital of Eastern Ontario, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Ferris","sequence":"additional","affiliation":[{"name":"University of Ottawa"},{"name":"Children's Hospital of Eastern Ontario, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn D.","family":"Aaron","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital"},{"name":"University of Ottawa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Chan","sequence":"additional","affiliation":[{"name":"University of Ottawa"},{"name":"Children's Hospital of Eastern Ontario, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Lee","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital"},{"name":"University of Ottawa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karam","family":"Ramotar","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital"},{"name":"University of Ottawa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.4.9907147"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.11.4172-4179.2002"},{"key":"e_1_3_2_4_2","first-page":"89","year":"2000","unstructured":"Anderson, J. M., and R. E. Marchant. 2000. Biomaterials: factors favoring colonization and infection, p. 89-109. In F. A. Waldvogel and A. L. Bisno (ed.), Infections associated with biomedical devices, 3rd ed. ASM Press, Washington, D.C.","journal-title":"Infections associated with biomedical devices"},{"key":"e_1_3_2_5_2","first-page":"48","volume":"48","year":"2001","unstructured":"Andrews, J., and BSAC Working Party Report on Susceptibility Testing. 2001. Determination of inhibitory concentrations. J. Antimicrob. Chemother.48(Suppl. 1):48-71.","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.6.1771-1776.1999"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5418.1318"},{"key":"e_1_3_2_8_2","first-page":"S47","year":"2000","unstructured":"Donlan, R. M. 2000. Role of biofilms in antimicrobial resistance. ASAIO J.S47-S52.","journal-title":"ASAIO J."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.6.1214"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.6.2005018"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15266-X"},{"key":"e_1_3_2_12_2","unstructured":"National Committee for Clinical Laboratory Standards. 2003. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard M7-A6. National Committee for Clinical Laboratory Standards Wayne Pa."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05321-1"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/377239"},{"key":"e_1_3_2_15_2","unstructured":"Infections associated with indwelling medical devices 2000"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra040181"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.19.1537"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.50.1.55-61.2006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.50.1.55-61.2006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T19:03:22Z","timestamp":1645470202000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.50.1.55-61.2006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1128\/AAC.50.1.55-61.2006"],"URL":"https:\/\/doi.org\/10.1128\/aac.50.1.55-61.2006","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"2005-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-10-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}