{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T11:19:51Z","timestamp":1789903191226,"version":"4.0.1"},"reference-count":50,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Eleven\n            <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n            clinical isolates and one\n            <jats:italic>Klebsiella oxytoca<\/jats:italic>\n            clinical isolate showing various pulsed-field gel electrophoresis types and producing an inducible DHA-1 class C \u03b2-lactamase were isolated in the Parisian region between 1998 and 2003. The aim of this study was to compare the genetic organization of the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>DHA-1<\/jats:sub>\n            genes in this collection of clinical isolates. In four isolates, the\n            <jats:italic>Morganella morganii<\/jats:italic>\n            -derived genomic region containing\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>DHA-1<\/jats:sub>\n            was inserted in an entire complex\n            <jats:italic>sul1<\/jats:italic>\n            -type integron, including a region common to In6-In7 (CR1), as previously described in a\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>DHA-1<\/jats:sub>\n            -producing\n            <jats:italic>Salmonella enterica<\/jats:italic>\n            serovar Enteritidis KF92 isolate from Saudi Arabia in 1992. Different gene cassette arrays were characterized in each of these integrons. In two of them, an additional 10-kb fragment was inserted between the CR1 and the\n            <jats:italic>M. morganii<\/jats:italic>\n            -derived region and was similar to the\n            <jats:italic>sap<\/jats:italic>\n            (ABC transporter family) and\n            <jats:italic>psp<\/jats:italic>\n            (phage shock protein) operons originated from\n            <jats:italic>Salmonella enterica<\/jats:italic>\n            serovar Typhimurium. The length of the\n            <jats:italic>M. morganii<\/jats:italic>\n            region was variable, suggesting that several independent recombination events have occurred and that open reading frame\n            <jats:italic>orf513<\/jats:italic>\n            encodes a recombinase involved in the mobilization of the resistance genes. The genetic organization of\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>DHA-1<\/jats:sub>\n            was identical in the eight other isolates. This structure is likely derived from a complex integron following the insertion of IS\n            <jats:italic>26<\/jats:italic>\n            , leading to the deletion of the first part of integron. The horizontal transfer of one plasmid carrying that truncated integron was shown for seven of these isolates.\n          <\/jats:p>","DOI":"10.1128\/aac.50.2.607-617.2006","type":"journal-article","created":{"date-parts":[[2006,1,25]],"date-time":"2006-01-25T21:53:41Z","timestamp":1138226021000},"page":"607-617","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":83,"title":["Emergence of DHA-1-Producing\n            <i>Klebsiella<\/i>\n            spp. in the Parisian Region: Genetic Organization of the\n            <i>ampC<\/i>\n            and\n            <i>ampR<\/i>\n            Genes Originating from\n            <i>Morganella morganii<\/i>"],"prefix":"10.1128","volume":"50","author":[{"given":"Charlotte","family":"Verdet","sequence":"first","affiliation":[{"name":"Service de Bacte\u0301riologie, Ho\u0302pital Tenon, Paris, France"},{"name":"UPRES EA 2392 UFR Saint-Antoine Universite\u0301 Paris VI, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahia","family":"Benzerara","sequence":"additional","affiliation":[{"name":"Service de Bacte\u0301riologie, Ho\u0302pital Tenon, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vale\u0301rie","family":"Gautier","sequence":"additional","affiliation":[{"name":"UPRES EA 2392 UFR Saint-Antoine Universite\u0301 Paris VI, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Adam","sequence":"additional","affiliation":[{"name":"Service de Microbiologie Me\u0301dicale, Institut Gustave Roussy, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahia","family":"Ould-Hocine","sequence":"additional","affiliation":[{"name":"Service de Bacte\u0301riologie, Ho\u0302pital Henri Mondor, Cre\u0301teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Arlet","sequence":"additional","affiliation":[{"name":"Service de Bacte\u0301riologie, Ho\u0302pital Tenon, Paris, France"},{"name":"UPRES EA 2392 UFR Saint-Antoine Universite\u0301 Paris VI, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3389"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80360-2"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.2.533-537.2004"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1097(97)00006-2"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.9.2352"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.1.221"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg590"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.6.1714-1722.2002"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.4.933-951.2001"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.3.563"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/514938"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkf193"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.8.2427-2434.2002"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/47.2.207"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/39.1.85"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.7.1736"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-7646(98)80026-5"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.7.1759"},{"key":"e_1_3_2_20_2","first-page":"214","volume":"34","year":"2004","unstructured":"Kim, J. 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