{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:14:08Z","timestamp":1791288848855,"version":"4.3.0"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Pandoraea<\/jats:italic>\n            spp. are gram-negative, glucose nonfermenting rods detectable in blood cultures and sputa of cystic fibrosis patients. They are resistant to various antibiotic groups, with imipenem being the only active \u03b2-lactam. We isolated an imipenem-resistant (MIC, 64 \u03bcg\/ml)\n            <jats:italic>Pandoraea pnomenusa<\/jats:italic>\n            strain from a cystic fibrosis patient. Cloning and sequencing identified two \u03b2-lactamases of Bush group 2d, namely, the known OXA-33, located on an integron, and the novel carbapenem-hydrolyzing oxacillinase OXA-62. OXA-62 is only distantly related to other oxacillinases (OXA-50 being closest with 43% amino acid identity). It hydrolyzes penicillins, oxacillin, imipenem, and meropenem but not expanded-spectrum cephalosporins. The\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>OXA-62<\/jats:sub>\n            gene is chromosome located. No transposable elements were found in its genetic neighborhood. With OXA-62-specific primers,\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>OXA-62<\/jats:sub>\n            could be identified in all\n            <jats:italic>P. pnomenusa<\/jats:italic>\n            strains and appears to be species specific. This additional mechanism of carbapenem resistance further complicates the treatment of infections caused by\n            <jats:italic>P. pnomenusa<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.50.4.1330-1335.2006","type":"journal-article","created":{"date-parts":[[2006,3,28]],"date-time":"2006-03-28T22:03:12Z","timestamp":1143583392000},"page":"1330-1335","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":46,"title":["Novel Carbapenem-Hydrolyzing Oxacillinase OXA-62 from\n            <i>Pandoraea pnomenusa<\/i>"],"prefix":"10.1128","volume":"50","author":[{"given":"Ines","family":"Schneider","sequence":"first","affiliation":[{"name":"MICOER Institute, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Marie","family":"Queenan","sequence":"additional","affiliation":[{"name":"Johnson &amp; Johnson Pharmaceutical Research and Development, Raritan, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolf","family":"Bauernfeind","sequence":"additional","affiliation":[{"name":"MICOER Institute, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.2.583-588.2001"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.9.2041"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.8.1924"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkf069"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.6.1556-1561.2000"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-50-2-887"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.33.9.1580"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1992.tb00894.x"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.5.1819-1826.2001"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.6.2043-2048.2004"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.11.4217-4225.2004"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.1.268-273.2003"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.5.1670-1675.2004"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000136857.74561.3c"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/dnares\/7.6.331"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.1.227"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/09674845.2002.11978036"},{"key":"e_1_3_1_19_2","unstructured":"National Center for Clinical and Laboratory Standards. 2002. Performance standards for antimicrobial susceptibility testing 12th informational supplement. M100-S12. National Center for Clinical and Laboratory Standards Wayne Pa."},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0924-8579(93)90045-7"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.10.2557"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.5.2255-2257.2003"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.21.1.85"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1097(03)00510-X"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.50.4.1330-1335.2006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.50.4.1330-1335.2006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T19:09:07Z","timestamp":1645470547000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.50.4.1330-1335.2006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1128\/AAC.50.4.1330-1335.2006"],"URL":"https:\/\/doi.org\/10.1128\/aac.50.4.1330-1335.2006","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4]]},"assertion":[{"value":"2005-10-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-02-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}