{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:24:24Z","timestamp":1773296664007,"version":"3.50.1"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Aerosolized\nevaporative precipitation into aqueous solution and spray freezing into\nliquid nanostructured formulations of itraconazole as prophylaxis\nsignificantly improved survival relative to commercial itraconazole\noral solution and the control in a murine model of invasive pulmonary\naspergillosis. Aerosolized administration of nanostructured\nformulations also achieved high lung tissue concentrations while\nlimiting systemic\nexposure.<\/jats:p>","DOI":"10.1128\/aac.50.4.1552-1554.2006","type":"journal-article","created":{"date-parts":[[2006,3,28]],"date-time":"2006-03-28T22:03:12Z","timestamp":1143583392000},"page":"1552-1554","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":43,"title":["In Vivo Efficacy of Aerosolized Nanostructured ItraconazoleFormulations for Prevention of Invasive Pulmonary Aspergillosis"],"prefix":"10.1128","volume":"50","author":[{"given":"Barbara J.","family":"Hoeben","sequence":"first","affiliation":[{"name":"The\rUniversity of Texas at Austin College of\rPharmacy"},{"name":"The University of Texas\rHealth Science Center at San Antonio, San Antonio,Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Burgess","sequence":"additional","affiliation":[{"name":"The\rUniversity of Texas at Austin College of\rPharmacy"},{"name":"The University of Texas\rHealth Science Center at San Antonio, San Antonio,Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason T.","family":"McConville","sequence":"additional","affiliation":[{"name":"The\rUniversity of Texas at Austin College of\rPharmacy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura K.","family":"Najvar","sequence":"additional","affiliation":[{"name":"The University of Texas\rHealth Science Center at San Antonio, San Antonio,Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L.","family":"Talbert","sequence":"additional","affiliation":[{"name":"The\rUniversity of Texas at Austin College of\rPharmacy"},{"name":"The University of Texas\rHealth Science Center at San Antonio, San Antonio,Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay I.","family":"Peters","sequence":"additional","affiliation":[{"name":"The University of Texas\rHealth Science Center at San Antonio, San Antonio,Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan P.","family":"Wiederhold","sequence":"additional","affiliation":[{"name":"The\rUniversity of Texas at Austin College of\rPharmacy"},{"name":"The University of Texas\rHealth Science Center at San Antonio, San Antonio,Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradi L.","family":"Frei","sequence":"additional","affiliation":[{"name":"The\rUniversity of Texas at Austin College of\rPharmacy"},{"name":"The University of Texas\rHealth Science Center at San Antonio, San Antonio,Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Graybill","sequence":"additional","affiliation":[{"name":"The University of Texas\rHealth Science Center at San Antonio, San Antonio,Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosie","family":"Bocanegra","sequence":"additional","affiliation":[{"name":"The University of Texas\rHealth Science Center at San Antonio, San Antonio,Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirk A.","family":"Overhoff","sequence":"additional","affiliation":[{"name":"The\rUniversity of Texas at Austin College of\rPharmacy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prapasri","family":"Sinswat","sequence":"additional","affiliation":[{"name":"The\rUniversity of Texas at Austin College of\rPharmacy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith P.","family":"Johnston","sequence":"additional","affiliation":[{"name":"The University of Texas at\rAustin College of Engineering,,\rAustin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Robert O.","family":"Williams","sequence":"additional","affiliation":[{"name":"The\rUniversity of Texas at Austin College of\rPharmacy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(98)00102-3"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/34.6.1001"},{"key":"e_1_3_2_4_2","first-page":"299","volume":"14","year":"2005","unstructured":"Chen, X., Z. Benhayoune, R. O. Williams III, and K. P. Johnston. 2005. Rapid dissolution of high potency itraconazole particles produced by evaporative precipitation into aqueous solution. J. Drug Deliv. Sci. Tech.14:299-304.","journal-title":"J. Drug Deliv. Sci. Tech."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2003.09.028"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.2.379"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.7.3028-3030.2005"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(97)00062-9"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1081\/DDC-120030422"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.3.945-951.2005"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2644"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2512"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1081\/DDC-43983"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.3.758-764.2004"},{"key":"e_1_3_2_15_2","unstructured":"NCCLS. 2002\n. Reference method for broth dilution antifungal\nsusceptibility testing of filamentous fungi: approved standard [NCCLS\ndocument M38A]. NCCLS Wayne Pa."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg434"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-103-25677"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(02)00154-0"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0939-6411(02)00063-2"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/48.1.89"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(02)00072-8"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2005.06.027"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1086\/421950"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-9-200305060-00006"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.50.4.1552-1554.2006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.50.4.1552-1554.2006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T19:11:27Z","timestamp":1645470687000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.50.4.1552-1554.2006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1128\/AAC.50.4.1552-1554.2006"],"URL":"https:\/\/doi.org\/10.1128\/aac.50.4.1552-1554.2006","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4]]},"assertion":[{"value":"2005-10-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-01-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}