{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:38:20Z","timestamp":1791938300858,"version":"4.3.4"},"reference-count":39,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    As part of our search for new antifungal agents from natural resources, 22 C-27 steroidal saponins and 6 steroidal sapogenins isolated from several monocotyledonous plants were tested for their antifungal activity against the opportunistic pathogens\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    ,\n                    <jats:italic>Candida glabrata<\/jats:italic>\n                    ,\n                    <jats:italic>Candida krusei<\/jats:italic>\n                    ,\n                    <jats:italic>Cryptococcus neoformans<\/jats:italic>\n                    , and\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    . The results showed that the antifungal activity of the steroidal saponins was associated with their aglycone moieties and the number and structure of monosaccharide units in their sugar chains. Within the 10 active saponins, four tigogenin saponins (compounds 1 to 4) with a sugar moiety of four or five monosaccharide units exhibited significant activity against\n                    <jats:italic>C. neoformans<\/jats:italic>\n                    and\n                    <jats:italic>A. fumigatus<\/jats:italic>\n                    , comparable to the positive control amphotericin B. The antifungal potency of these compounds was not associated with cytotoxicity to mammalian cells. This suggests that the C-27 steroidal saponins may be considered potential antifungal leads for further preclinical study.\n                  <\/jats:p>","DOI":"10.1128\/aac.50.5.1710-1714.2006","type":"journal-article","created":{"date-parts":[[2006,4,26]],"date-time":"2006-04-26T18:58:47Z","timestamp":1146077927000},"page":"1710-1714","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":170,"title":["Antifungal Activity of C-27 Steroidal Saponins"],"prefix":"10.1128","volume":"50","author":[{"given":"Chong-Ren","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa R.","family":"Jacob","sequence":"additional","affiliation":[{"name":"National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi 38677"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabana I.","family":"Khan","sequence":"additional","affiliation":[{"name":"National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi 38677"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Cong","family":"Li","sequence":"additional","affiliation":[{"name":"National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi 38677"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"491","volume":"57","year":"2002","unstructured":"Bedir, E., I. 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