{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T02:40:28Z","timestamp":1776048028590,"version":"3.50.1"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Rats immunosuppressed by the administration of cyclophosphamide and cortisone acetate and then infected with\n            <jats:italic>Aspergillus fumigatus<\/jats:italic>\n            were treated with an antifungal drug, EDTA, or a combination of one of the antifungal agents, amphotericin B lipid complex (ABLC; 5 mg\/kg of body weight\/day for 7 days), and EDTA (30 mg\/kg\/day for 7 days). The mortality rate was reduced, the duration of survival was increased, fewer\n            <jats:italic>A. fumigatus<\/jats:italic>\n            organisms were recovered from the lungs, and less-severe lung lesions were seen histopathologically in the rats receiving the combination treatment than in the rats receiving either an antifungal agent or EDTA alone. Further studies regarding the mechanisms of EDTA and its interactions with ABLC are warranted, and further studies are needed to more fully examine the safety, tolerance, and optimal dosing of EDTA in the treatment of this and other fungal infections.\n          <\/jats:p>","DOI":"10.1128\/aac.50.5.1823-1827.2006","type":"journal-article","created":{"date-parts":[[2006,4,26]],"date-time":"2006-04-26T22:58:47Z","timestamp":1146092327000},"page":"1823-1827","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":28,"title":["EDTA as an Adjunct Antifungal Agent for Invasive Pulmonary Aspergillosis in a Rodent Model"],"prefix":"10.1128","volume":"50","author":[{"given":"Ray","family":"Hachem","sequence":"first","affiliation":[{"name":"Departments of Infectious Diseases, Infection Control and Employee Health"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Bahna","sequence":"additional","affiliation":[{"name":"Departments of Infectious Diseases, Infection Control and Employee Health"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hend","family":"Hanna","sequence":"additional","affiliation":[{"name":"Departments of Infectious Diseases, Infection Control and Employee Health"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Clifton","family":"Stephens","sequence":"additional","affiliation":[{"name":"Veterinary Medicine and Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Issam","family":"Raad","sequence":"additional","affiliation":[{"name":"Departments of Infectious Diseases, Infection Control and Employee Health"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","first-page":"47","volume":"54","year":"1996","unstructured":"Andriole, V. T. 1996. Aspergillus infections: problems in diagnosis and treatment. Infect. Agents Dis.54:47-54.","journal-title":"Infect. 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National Academy Press Washington D.C."},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200007000-00006"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.12.3381-3388.2000"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.33936"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2000.109640"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.3.540-545.2000"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200201243460403"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.6.2336-2342.2005"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.50.5.1823-1827.2006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.50.5.1823-1827.2006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T19:03:04Z","timestamp":1645470184000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.50.5.1823-1827.2006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1128\/AAC.50.5.1823-1827.2006"],"URL":"https:\/\/doi.org\/10.1128\/aac.50.5.1823-1827.2006","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5]]},"assertion":[{"value":"2005-08-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-02-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}