{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:53:57Z","timestamp":1761058437510,"version":"3.32.0"},"reference-count":14,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Nebulized amphotericin B (AMB) combined with intravenous AMB was studied in persistently leukopenic rats with invasive pulmonary aspergillosis. Pulmonary concentrations of AMB after aerosol treatment were substantially higher than after intravenous liposomal AMB. Nebulized liposomal AMB in addition to intravenous AMB resulted in significantly prolonged survival compared to controls.<\/jats:p>","DOI":"10.1128\/aac.50.5.1852-1854.2006","type":"journal-article","created":{"date-parts":[[2006,4,26]],"date-time":"2006-04-26T22:58:47Z","timestamp":1146092327000},"page":"1852-1854","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Nebulized Amphotericin B Combined with Intravenous Amphotericin B in Rats with Severe Invasive Pulmonary Aspergillosis"],"prefix":"10.1128","volume":"50","author":[{"given":"Elisabeth J.","family":"Ruijgrok","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel H. A. M.","family":"Fens","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irma A. J. M.","family":"Bakker-Woudenberg","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Els W. M.","family":"van Etten","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnold G.","family":"Vulto","sequence":"additional","affiliation":[{"name":"Hospital Pharmacy, Erasmus University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","first-page":"19","volume":"18","year":"1998","unstructured":"Andriole, V. T. 1998. Current and future therapy of invasive fungal infections, p. 19-36. In J. Remington and M. Schwartz (ed.), Current clinical topics in infectious diseases,vol. 18. Blackwell Sciences, Malden, Mass.","journal-title":"Current clinical topics in infectious diseases"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.22.6.1042"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkf010"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510260223"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/513943"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/22.1.133"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/js9604218"},{"key":"e_1_3_1_9_2","first-page":"20","volume":"80","year":"1992","unstructured":"Lasic, D. 1992. Liposomes: synthetic lipid microspheres serve as multipurpose vehicles for the delivery of drugs, genetic material and cosmetics. Am. Sci.80:20-31.","journal-title":"Am. Sci."},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/38.2.215"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.1.29"},{"key":"e_1_3_1_12_2","first-page":"619","volume":"52","year":"2000","unstructured":"Ruijgrok, E. J., A. G. Vulto, and E. W. M. van Etten. 2000. Aerosol delivery of amphotericin B desoxycholate (Fungizone) and liposomal amphotericin B (AmBisome): aerosol characteristics and in-vivo amphotericin B deposition in rats. J. Pharm. Pharmacol.52:619-627.","journal-title":"J. Pharm. Pharmacol."},{"key":"e_1_3_1_13_2","first-page":"89","volume":"48","year":"2000","unstructured":"Ruijgrok, E. J., A. G. Vulto, and E. W. M. van Etten. 2000. Efficacy of aerosolized amphotericin B desoxycholate and liposomal amphotericin B in the treatment of invasive pulmonary aspergillosis in severely immunocompromised rats. J. Antimicrob. Chemother.48:89-95.","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_1_14_2","unstructured":"Schiffelers R. M. 2001. Liposomal targeting of antimicrobial agents to bacterial infections. Ph.D. thesis. Erasmus University Rotterdam Rotterdam The Netherlands."},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/35.4.509"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.50.5.1852-1854.2006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.50.5.1852-1854.2006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T19:02:02Z","timestamp":1645470122000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.50.5.1852-1854.2006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1128\/AAC.50.5.1852-1854.2006"],"URL":"https:\/\/doi.org\/10.1128\/aac.50.5.1852-1854.2006","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"type":"print","value":"0066-4804"},{"type":"electronic","value":"1098-6596"}],"subject":[],"published":{"date-parts":[[2006,5]]},"assertion":[{"value":"2004-09-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-03-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}