{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:15:45Z","timestamp":1756995345310},"reference-count":0,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1974,7,1]],"date-time":"1974-07-01T00:00:00Z","timestamp":141868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1974,7]]},"abstract":"<jats:p>\n            Gentamicin was measured in the presence of clindamycin by using as the assay organism a strain of\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            that was resistant to clindamycin; clindamycin was measured in the presence of gentamicin by using\n            <jats:italic>Clostridium perfringens<\/jats:italic>\n            as the assay organism. Both assays were in agar diffusion systems, were rapid (2 to 4 h), and had errors of less than 10%. Neither antibiotic antagonized or synergized with the other against a variety of organisms. The pK of clindamycin was 7.3, and the pK of gentamicin was 8.2. Gentamicin was 100 or more times as active in alkaline medium against both gram-positive and gram-negative organisms, but clindamycin showed a striking pH effect on activity only with gram-positive organisms.\n          <\/jats:p>","DOI":"10.1128\/aac.6.1.54","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"54-59","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":34,"title":["Rapid Microassays for Clindamycin and Gentamicin When Present Together and the Effect of pH and of Each on the Antibacterial Activity of the Other"],"prefix":"10.1128","volume":"6","author":[{"given":"L. D.","family":"Sabath","sequence":"first","affiliation":[{"name":"Channing Laboratory and Thorndike Memorial Laboratory, Harvard Medical Unit and Department of Medical Bacteriology, Boston City Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inge","family":"Toftegaard","sequence":"additional","affiliation":[{"name":"Channing Laboratory and Thorndike Memorial Laboratory, Harvard Medical Unit and Department of Medical Bacteriology, Boston City Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.6.1.54","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.6.1.54","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:06:52Z","timestamp":1645484812000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.6.1.54"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1974,7]]}},"alternative-id":["10.1128\/AAC.6.1.54"],"URL":"https:\/\/doi.org\/10.1128\/aac.6.1.54","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,7]]},"assertion":[{"value":"1974-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}