{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T03:01:14Z","timestamp":1772679674878,"version":"3.50.1"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1975,1,1]],"date-time":"1975-01-01T00:00:00Z","timestamp":157766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1975,1]]},"abstract":"<jats:p>\n            The comparative susceptibility of 622 recent clinical isolates of anaerobic bacteria to minocycline, doxycycline, and tetracycline was determined by an agar-dilution technique. In addition to\n            <jats:italic>Bacteroides fragilis<\/jats:italic>\n            , a variety of other anaerobic bacteria was resistant to achievable blood concentrations of tetracycline (55% inhibited by 6.25 \u03bcg\/ml) and doxycycline (58% inhibited by 2.5 \u03bcg\/ml). In contrast, minocycline was significantly more active (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.05) than both doxycycline and tetracycline, and 70% of strains were inhibited by achievable blood concentrations of this antibiotic (2.5 \u03bcg\/ml). The enhanced activity of minocycline was particularly striking for\n            <jats:italic>Peptococcus asaccharolyticus, P. magnus, P. prevotii, Peptostreptococcus anaerobius<\/jats:italic>\n            , and\n            <jats:italic>Bacteroides melaninogenicus<\/jats:italic>\n            . Further evaluation of the clinical efficacy of minocycline against anaerobic infections is indicated.\n          <\/jats:p>","DOI":"10.1128\/aac.7.1.46","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T23:57:02Z","timestamp":1340841422000},"page":"46-49","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":44,"title":["Comparative Susceptibility of Anaerobic Bacteria to Minocycline, Doxycycline, and Tetracycline"],"prefix":"10.1128","volume":"7","author":[{"given":"Anthony W.","family":"Chow","sequence":"first","affiliation":[{"name":"Department of Medicine, Harbor General Hospital, Torrance, California 90509"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie","family":"Patten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucien B.","family":"Guze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.7.1.46","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.7.1.46","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T13:48:48Z","timestamp":1645451328000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.7.1.46"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1975,1]]}},"alternative-id":["10.1128\/AAC.7.1.46"],"URL":"https:\/\/doi.org\/10.1128\/aac.7.1.46","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,1]]},"assertion":[{"value":"1975-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}